RRAGA

3 papers2 findings

HGNC NCBI Gene Taxon

1 lab in 2 countries

Funders: Agencia Estatal de Investigación and 6 more

Animals2
Cells1

Effects

2

Hepatocellular carcinoma

no changein mice1

1 study

RRAGA has no effect on hepatocellular carcinoma in mice.
“Constitutive hepatic nutrient signaling does not cause hepatocellular damage and carcinomas”
Animalsin adult RagAGTP miceliver
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling
Nature communications16 Jun 2021

More on Hepatocellular carcinoma

Lifespan

downin mice1

1 study

RRAGA shortens lifespan in mice (9 months).
“median lifespan of nine months”
AnimalsGTP-locked RagA (RagAGTP)liver
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling
Nature communications16 Jun 2021

Latest

1 in 12 months

Nature Communications10 Jun

Corylin promotes healthy aging via RAGA-mTOR suppression and sex-dependent activation of SIRT3

Experiments in miceInterventions

Nature Communications16 Jun

Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling

Experiments in micePPAR signalling

Nature16 May

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing

Experiments in human cellsmTOR signalling