What does the research say about PHB2?

PHB2

There are 7 papers on PHB2 in aging research: 3 trials and 1 observational study in people, 2 in animals, 1 in cells. The newest story, Oct 28, 2026: “Blood protein levels changed after bone drug in older women”.

Gene

7 papers study it1 finding

HGNC NCBI Gene Taxon

See all 7

1 lab in 1 country

Funder: Natural Science Foundation of Guangdong Province

Human trial3
Humans1
Animals2
Cells1

Effects

Elamipretide

is required forin mouse cells1

1 study

PHB2 is required for elamipretide in mouse cells (knockdown of PHB2 in vitro).
“In vitro, knockdown of PHB2 and an STING agonist abolished the protective effect of SS-31.”
Cellsknockdown of PHB2 in vitro
SS-31 inhibits mtDNA-cGAS-STING signaling to improve POCD by activating mitophagy in aged mice
Inflammation research : official journal of the European Histamine Research Society ... [et al.]Feb 27, 2024

Funding

1 grant since 2026

Natural Science Foundation of Guangdong ProvinceCN¥100K

Study on a CRISPR/Cas9 nano-delivery system targeting the microglial ZPO1/PHB2 axis to regulate senescence mechanisms and promote repair of optic nerve injury in glaucoma
Natural Science Foundation of Guangdong ProvinceSouthern Medical UniversityCN¥100K2026

Latest

1 paper in 12 months

Signal Transduction and Targeted TherapyJul 15

Blood protein levels changed after bone drug in older women

Among 36 older women with low bone density, levels of about 400 blood proteins changed after zoledronate compared with levels before treatment.Among 36 older women with low bone density, levels of about 400 blood proteins changed after zoledronate compared with levels before treatment.

Randomized trial · 36 peopleInterventions