MIR125A

2 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab in 1 country

Funders: Jiangsu Science and Technology Department and 1 more

Human trial1
Animals1

Effects

bone-muscle crosstalk

mediatesin mice1

1 study

MIR125A mediates bone-muscle crosstalk in mice.
“Within the studies reviewed, miR-125a-5p is the most complete preclinical muscle-to-bone candidate pathway, but its Tier-A assignment is provisional and supports causality only in the reported mouse models”
Reviewin preclinical mouse models
Extracellular Vesicle-Mediated microRNA Signaling in Osteosarcopenia: Emerging Insights into Age-Related Bone-Muscle Crosstalk
Aging and disease28 Sep 2026

Osteogenic differentiation

downin mouse cells1

1 study

MIR125A inhibits osteogenic differentiation in mouse cells.
“miR-125a-5p inhibits osteogenic differentiation by directly targeting Sirt7 in preosteoblasts”
Cellsbone
Atrophic Skeletal Muscle-Derived Extracellular Vesicles Transfer miR-125a-5p to Inhibit Bone Formation in Osteoporosis during Aging
Advanced science (Weinheim, Baden-Wurttemberg, Germany)26 Feb 2026

Muscle atrophy

upin mice1

1 study

MIR125A increases muscle atrophy in mice.
“Muscle-specific overexpression of miR-125a-5p inhibited osteogenesis and exacerbated muscle atrophy and bone loss”
Animalsmuscle-specific overexpression
Atrophic Skeletal Muscle-Derived Extracellular Vesicles Transfer miR-125a-5p to Inhibit Bone Formation in Osteoporosis during Aging
Advanced science (Weinheim, Baden-Wurttemberg, Germany)26 Feb 2026