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MAPK15

Gene

4 papers study it10 findings

HGNCNCBI GeneTaxon

1 new paper in 30 daysSee all 4

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funders: Associazione Italiana per la Ricerca sul Cancro and 1 more
  • Humans1
  • Animals1
  • Cells1

Effects

8

Cellular senescence

downin human cells1downin mice1downin reviews1

3 studies

  1. MAPK15 decreases cellular senescence in mice.

    “overexpression of MAPK15 alleviated DSS-induced intestinal inflammation, reduced cellular senescence-like phenotype, and suppressed Drp1-dependent mitochondrial fission.”

    Animalsoverexpression of MAPK15 in DSS-induced mice

    MAPK15 Attenuates Intestinal Epithelial Cell Senescence-Like Phenotype to Regulate Gut Homeostasis and Inflammation by Phosphorylating Suz12 to Suppress Drp1-Mediated Mitochondrial Fission Damage

    Inflammation

  2. MAPK15 prevents cellular senescence.

    “preventing ROS accumulation, extensive DNA damage and activation of the cellular senescence phenotype”

    Review

    MAPK15 controls mitochondrial fitness and contributes to prevent cellular senescence

    Autophagy reports

  3. MAPK15 protects against cellular senescence in human cells.

    “MAPK15 protects primary human airway epithelial cells from senescence”

    Cellsprimary human airway epithelial cells

    MAPK15 protects from oxidative stress-dependent cellular senescence by inducing the mitophagic process

    Aging cell

More on Cellular senescence

Mitochondrial calcium overload

upin human cells1

1 study

  1. MAPK15 increases mitochondrial calcium overload in human cells.

    “MAPK15 promotes mitochondrial calcium overload through palmitoylation of Mcub at C91”

    Cellsthrough MCUB palmitoylation at C91atrial cardiomyocyte

    A protein promotes an irregular heartbeat in animals

    Cardiovascular research

Ulcerative colitis

downin mice1

1 study

  1. MAPK15 decreases ulcerative colitis in mice.

    “MAPK15 contributed to the inhibition of mitochondrial fission through regulation of the Suz12/Drp1 axis, thereby mitigating IEC senescence-like phenotype and suppressing the progression of UC.”

    Animalsin DSS-induced UC mice

    MAPK15 Attenuates Intestinal Epithelial Cell Senescence-Like Phenotype to Regulate Gut Homeostasis and Inflammation by Phosphorylating Suz12 to Suppress Drp1-Mediated Mitochondrial Fission Damage

    Inflammation

More on Ulcerative colitis

Mitochondrial fission and fusion

downin mice1

1 study

  1. MAPK15 inhibits mitochondrial fission and fusion in mice.

    “overexpression of MAPK15 alleviated DSS-induced intestinal inflammation, reduced cellular senescence-like phenotype, and suppressed Drp1-dependent mitochondrial fission.”

    Animalsoverexpression of MAPK15 in DSS-induced mice

    MAPK15 Attenuates Intestinal Epithelial Cell Senescence-Like Phenotype to Regulate Gut Homeostasis and Inflammation by Phosphorylating Suz12 to Suppress Drp1-Mediated Mitochondrial Fission Damage

    Inflammation

More on Mitochondrial fission and fusion

Inflammation

downin mice1

1 study

  1. MAPK15 decreases inflammation in mice.

    “overexpression of MAPK15 alleviated DSS-induced intestinal inflammation, reduced cellular senescence-like phenotype, and suppressed Drp1-dependent mitochondrial fission.”

    Animalsoverexpression of MAPK15 in DSS-induced mice

    MAPK15 Attenuates Intestinal Epithelial Cell Senescence-Like Phenotype to Regulate Gut Homeostasis and Inflammation by Phosphorylating Suz12 to Suppress Drp1-Mediated Mitochondrial Fission Damage

    Inflammation

More on Inflammation

Oxidative stress and ROS signaling

downin reviews1

1 study

  1. MAPK15 prevents oxidative stress and ROS signaling.

    “thereby preventing ROS accumulation, extensive DNA damage and activation of the cellular senescence phenotype”

    Review

    MAPK15 controls mitochondrial fitness and contributes to prevent cellular senescence

    Autophagy reports

More on Oxidative stress and ROS signaling

Mitophagy

upin human cells1

1 study

  1. MAPK15 induces mitophagy in human cells.

    “MAPK15 controls the mitophagic process by stimulating ULK1-dependent PRKN Ser108 phosphorylation”

    Cells

    MAPK15 protects from oxidative stress-dependent cellular senescence by inducing the mitophagic process

    Aging cell

More on Mitophagy

Mitochondrial ROS

downin human cells1

1 study

  1. MAPK15 decreases mitochondrial ROS in human cells.

    “while increasing mitochondrial ROS levels”

    Cellsreduced MAPK15 expression

    MAPK15 protects from oxidative stress-dependent cellular senescence by inducing the mitophagic process

    Aging cell

More on Mitochondrial ROS

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 1May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 12 papers in 12 months
Cardiovascular Research

A protein promotes an irregular heartbeat in animals

Animal experiments found that raising levels of the protein MAPK15 worsened heart muscle cell senescence and promoted atrial fibrillation, an irregular heartbeat.Animal experiments found that raising levels of the protein MAPK15 worsened heart muscle cell senescence and promoted atrial fibrillation, an irregular heartbeat.

Animal studyMechanisms
Paper

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