Ulcerative colitis

1. CD8+ T cell raises the risk of ulcerative colitis in humans.

   Animalsmucosa

   NAD⁺ Metabolic Reprogramming Drives CD8⁺ T Cells Senescence and Exacerbates Ulcerative Colitis · Aging cell · 1 Sep 2026

1. Semaglutide is associated with ulcerative colitis in humans (72.5% vs 60%; OR 1.77).

   Humanscompared with liraglutide for remission rates12 weeksn = 150

   GLP-1 receptor agonist therapy is associated with increased symptomatic remission in ulcerative colitis: a matched cohort study · Inflammatory bowel diseases · 21 Aug 2026

Semaglutide →

1. GLP-1 receptor agonists are associated with ulcerative colitis in humans (adjusted OR 5.90, 95% CI 3.52-9.86).

   Humansadjusted odds of symptomatic remission at 12 weeks12 weeks

   GLP-1 receptor agonist therapy is associated with increased symptomatic remission in ulcerative colitis: a matched cohort study · Inflammatory bowel diseases · 21 Aug 2026

GLP-1 receptor agonists →