FSTL1

1. FSTL1 increases intervertebral disc degeneration in O. cuniculus.

   “rabbit IVDD model experiments demonstrated that the specific FSTL1 siRNA markedly repressed the development of IVDD”

   Animalsshown by siRNA silencing in rabbit puncture model

   FSTL1 Accelerates Nucleus Pulposus Cell Senescence and Intervertebral Disc Degeneration Through TLR4/NF-κB Pathway

   Inflammation·Feb 6, 2024

More on Intervertebral disc degeneration

1. FSTL1 induces cellular senescence in human cells.

   “recombinant human FSTL1 (rh-FSTL1) was found to upregulate the expression of p16 and p21, increase the number of senescence-associated β-galactosidase (SA-β-gal)-positive cells”

   Cellsin nucleus pulposus cells

   FSTL1 Accelerates Nucleus Pulposus Cell Senescence and Intervertebral Disc Degeneration Through TLR4/NF-κB Pathway

   Inflammation·Feb 6, 2024

More on Cellular senescence

1. FSTL1 increases alveolar epithelial cell senescence in cells.

   “TGFβ1-induced FSTL1 not only promoted AECs senescence, but also upregulated SENP1 expression.”

   CellsTGFβ1-induced FSTL1alveolar epithelial cells

   FSTL1 Promotes Alveolar epithelial cells Aging and Worsens Pulmonary Fibrosis by Affecting SENP1-Mediated DeSUMOylation

   Research Square·Jun 14, 2022Preprint