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FGF7

Gene

5 papers2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Key R&D Program of China and 1 more
  • Animals5

Effects

2

Stem cell differentiation

upin mouse cells1

1 study

  1. FGF7 induces stem cell differentiation in mouse cells.

    “FGF7 induced the osteogenic differentiation of SSCs but inhibited osteoclastogenesis in a concentration-dependent manner”

    Cellsin vitroconcentration-dependent

    Modulation of senescent Lepr⁺ skeletal stem cells via suppression of leptin-induced STAT3‒FGF7 axis activation alleviates abnormal subchondral bone remodeling and osteoarthritis progression

    Stem cell research & therapy5 May 2025

More on Stem cell differentiation

Osteoarthritis

upin mice1

1 study

  1. FGF7 increases osteoarthritis in mice.

    “FGF7 exacerbated abnormal bone remodeling in subchondral bones and OA progression by enhancing bone formation and suppressing bone resorption”

    Animalsin vivosubchondral bone

    Modulation of senescent Lepr⁺ skeletal stem cells via suppression of leptin-induced STAT3‒FGF7 axis activation alleviates abnormal subchondral bone remodeling and osteoarthritis progression

    Stem cell research & therapy5 May 2025

More on Osteoarthritis

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