Female infertility

1. TGF-β signalling is associated with female infertility in humans.

   “Fibro-inflammatory pathways, including transforming growth factor-β (TGF-β), Hippo/YAP-TAZ signaling, oxidative stress, macrophage activation, and mechanotransduction, are increasingly associated with ovarian ageing, polycystic ovary syndrome, reduced ovarian reserve”

   Reviewovaryfemales

   The Fibro-Inflammatory Ovary: Stromal Fibrosis, Extracellular Matrix Remodeling, and Mechanotransduction in Female Infertility · Current issues in molecular biology · 8 Sep 2026

TGF-β signalling →

1. Chronic inflammation is associated with female infertility in humans.

   “Progressive extracellular matrix remodeling, stromal fibrosis, chronic inflammation, and heightened tissue stiffness seem to affect follicular homeostasis, granulosa-oocyte communication, and ovarian function.”

   Reviewovaryfemales

   The Fibro-Inflammatory Ovary: Stromal Fibrosis, Extracellular Matrix Remodeling, and Mechanotransduction in Female Infertility · Current issues in molecular biology · 8 Sep 2026

Chronic inflammation →