Cbl

1. Cbl decreases insulin biosynthesis in rat cells.

   “knockdown of c-Cbl in INS-1 cells, a rat β-cell line, also increased insulin biosynthesis and glucose-stimulated secretion”

   Cellsin INS-1 cellsINS-1

   Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster

   Molecular and cellular biology·9 Jul 2012

1. Cbl inhibits insulin/IGF-1 signalling in flies.

   “dCbl deficiency in either the brain or insulin-producing cells upregulated the expression of dilp genes”

   Model organismsneuronal knockdownbrain

   Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster

   Molecular and cellular biology·9 Jul 2012

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