Vitiligo

5 papers2 findings

Humans1

Associations

2

Fibroblast

mixedin humans1

1 study

fibroblast is associated with vitiligo in humans.
“growing evidence suggests the involvement of dermal fibroblasts, residing deeper in the skin.”
Reviewskin
Emerging Role of Fibroblasts in Vitiligo: A Formerly Underestimated Rising Star
The Journal of investigative dermatology15 Mar 2024

Cellular senescence

upin humans1

1 study

Vitiligo is associated with cellular senescence in humans.
“Non-responding lesions exhibited acanthotic epidermis, had low number of total, proliferative, and differentiated melanocyte (MC) populations, and increased number of senescent keratinocytes (KCs)”
Human trialafter 6 months of NBUVB treatmentskin
Vitiligo non-responding lesions to narrow band UVB have intriguing cellular and molecular abnormalities that may prevent epidermal repigmentation
Pigment cell & melanoma research11 Feb 2024

More on Cellular senescence

Trial sponsors

Incyte
Company4 trialsPhase 3730 people
South Valley University
2 trialsPhase 4140 people
Dow University of Health Sciences
1 trialPhase 4120 people
Assiut University
1 trialPhase 450 people
Mahidol University
1 trialPhase 430 people
Cairo University
1 trialPhase 422 people
University Hospital, Ghent
1 trialPhase 414 people
University Hospital, Bordeaux
3 trialsPhase 3123 people

Latest

2 in 12 months

Burns & Trauma5 May

Mitochondrial dynamics in skin health and disease: energy, aging, and therapeutic perspectives

ReviewMitochondrial fission and fusion

Biology Direct7 Dec

Autophagy and mitophagy in dermatological disease: a comprehensive review from molecular pathways to therapeutic frontiers

ReviewMitophagy

Experimental Gerontology28 Sep

Regulatory mechanisms of transforming growth factor-β in senescence of fibroblast associated with refractory skin diseases

ReviewCell cycle regulation

Biochimica et Biophysica Acta Molecular Cell Research2 Jun

MitoQ for vitiligo by mitigating PARP1 translocation aberrations: Network pharmacology and experimental validation

Experiments in cellsInterventions

Inflammation Research29 Apr

The IL-6 autocrine loop promoting IFN-γ-induced fibroblast senescence is involved in psychological stress-mediated exacerbation of vitiligo

Experiments in animalsMechanisms

Free Radical Biology & Medicine15 Dec

Deciphering the role of skin aging in pigmentary disorders

ReviewMechanisms

Frontiers in Immunology25 Nov

Exploring mechanisms of skin aging: insights for clinical treatment

ReviewMechanisms

Cell Metabolism17 Oct

Lighting up arginine metabolism reveals its functional diversity in physiology and pathology

Study in peopleMechanisms

Human Immunology17 May

Implication of regulatory T cells' telomere shortening in pathogenesis of generalized vitiligo

Study in peopleMechanisms

The Journal of Investigative Dermatology17 Mar

Emerging Role of Fibroblasts in Vitiligo: A Formerly Underestimated Rising Star

ReviewMechanisms