CDK inhibitors

1 paper

Latest

3 in 12 months

Cancer Research21 Sep

Senolytic Interventions Enhance the Anti-metastatic Activity of Chemotherapy in Prostate Cancer

Experiments in miceSenolytics

Neurobiology of Disease12 May

Suppression of neuronal p27 impairs cognitive function in middle-aged mice

Experiments in miceMechanisms

Journal of Cell Science7 Nov

MRTF-dependent cytoskeletal dynamics drive efficient cell cycle progression

Experiments in mouse cellsCell cycle regulation

Experimental Gerontology28 Sep

Regulatory mechanisms of transforming growth factor-β in senescence of fibroblast associated with refractory skin diseases

ReviewCell cycle regulation

Molecular Cell27 Aug

A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision

Experiments in human cellsCell cycle regulation

iScience24 Mar

Programmed cell senescence is required for sensory organ development in Drosophila

Experiments in model organismsMechanisms

The EMBO Journal1 Oct

p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb

Experiments in animalsMechanisms

Cell Death & Disease30 May

Combined inhibition of class 1-PI3K-alpha and delta isoforms causes senolysis by inducing p21WAF1/CIP1 proteasomal degradation in senescent cells

Experiments in cellsInterventions

PeerJ24 Oct

Tissue-specific expression of senescence biomarkers in spontaneously hypertensive rats: evidence of premature aging in hypertension

Experiments in animalsMechanisms

Anticancer Research28 Jul

Histone H1.2 Represses the Transcription of the p16 Tumor Suppressor Gene

Experiments in cellsMechanisms