AP20187
Intervention1 paper4 findingsPubChem 78357784ChEBI 136847
- Animals1
Outcomes
4P16-POSITIVE fibroblasts
downin mice1Very low certainty
1 study
P16-POSITIVE fibroblasts
downin mice1Very low certainty
AP20187 decreases P16-POSITIVE fibroblasts in mice.
Animalsagingheart
Clearance of p16-positive cardiac cells improves age-related cardiac remodeling in mice · Experimental physiology · 14 Sep 2026
Diastolic dysfunction
downin mice1Very low certainty
1 study
Diastolic dysfunction
downin mice1Very low certainty
AP20187 decreases diastolic dysfunction in mice.
Animalsagingheart
Clearance of p16-positive cardiac cells improves age-related cardiac remodeling in mice · Experimental physiology · 14 Sep 2026
Anterior wall thickness at end diastole
downin mice1Very low certainty
1 study
Anterior wall thickness at end diastole
downin mice1Very low certainty
AP20187 decreases anterior wall thickness at end diastole in mice.
Animalsagingheart
Clearance of p16-positive cardiac cells improves age-related cardiac remodeling in mice · Experimental physiology · 14 Sep 2026
Left ventricular mass to diameter at end-diastole
downin mice1Very low certainty
1 study
Left ventricular mass to diameter at end-diastole
downin mice1Very low certainty
AP20187 decreases left ventricular mass to diameter at end-diastole in mice.
Animalsagingheart
Clearance of p16-positive cardiac cells improves age-related cardiac remodeling in mice · Experimental physiology · 14 Sep 2026