There are 6 papers on TDP-43 pathology in aging research: 5 observational studies in people, 1 review. The newest story, Oct 2, 2026: “Single-neuron sequencing reveals widespread low-frequency somatic mutations in dementia brains”.
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2 new papers in 30 daysSee all 69 papers on TDP-43 pathology
“In the posterior cingulate cortex, the association of TDP-43 with low mtDNAcn points to a vulnerability”
Mitochondrial DNA copy number
downin humans1
TDP-43 pathology is associated with mitochondrial DNA copy number in humans.
“In the posterior cingulate cortex, the association of TDP-43 with low mtDNAcn points to a vulnerability”
Humansposterior cingulate cortex
Molecular neurodegeneration
Progressive cognitive decline
downin humans1
TDP-43 pathology is associated with progressive cognitive decline in humans (effects increased over time).
“Alzheimer's disease pathology, macroscopic infarcts, Lewy bodies, TDP-43 pathology, and hippocampal sclerosis were associated with progressive cognitive decline, with their deleterious effects increasing over time”
Humanseffects increased over timebrainn = 1,096
Varied effects of age-related neuropathologies on the trajectory of late life cognitive decline
Brain : a journal of neurology
Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.
Lewy body disease prevalence rose from 0.7% in individuals younger than 50 to 20.0% in those aged 90 and older across 2,480 autopsied human brains.Lewy body disease prevalence rose from 0.7% in individuals younger than 50 to 20.0% in those aged 90 and older across 2,480 autopsied human brains.
In mouse cell experiments, exposing supporting brain cells to dehydrocostus lactone for 24 hours reduced their harmful effects on nerve cells.In mouse cell experiments, exposing supporting brain cells to dehydrocostus lactone for 24 hours reduced their harmful effects on nerve cells.
Each extra copy was linked to lower odds of cancer history, with an odds ratio of 0.91 compared with one fewer copy.Each extra copy was linked to lower odds of cancer history, with an odds ratio of 0.91 compared with one fewer copy.