Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change is associated with Lewy body pathology in humans (OR 1.89, 95% CI 1.02–3.37).
“and LBP (OR = 1.89; 95% CI 1.02-3.37; p = 0.036).”
HumansLATE-NC stages 2-3; adjusted for sociodemographic, clinical, and other neuropathologic covariatesbrain49.1% femalesn = 1,860
The changes were linked to a 4.06-point higher dementia rating score, compared with 3.78 points for moderate or severe Alzheimer’s-related changes.The changes were linked to a 4.06-point higher dementia rating score, compared with 3.78 points for moderate or severe Alzheimer’s-related changes.
Models identified symptom differences 12 years before mild cognitive impairment diagnosis and five years before dementia diagnosis in adults aged 60 or older.Models identified symptom differences 12 years before mild cognitive impairment diagnosis and five years before dementia diagnosis in adults aged 60 or older.
Among 833,417 patients, diagnosed voice disorders were linked to later cognitive decline, with a hazard ratio of 1.291 compared with matched controls.Among 833,417 patients, diagnosed voice disorders were linked to later cognitive decline, with a hazard ratio of 1.291 compared with matched controls.