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Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.
Lewy body disease prevalence rose from 0.7% in individuals younger than 50 to 20.0% in those aged 90 and older across 2,480 autopsied human brains.Lewy body disease prevalence rose from 0.7% in individuals younger than 50 to 20.0% in those aged 90 and older across 2,480 autopsied human brains.
In mouse cell experiments, exposing supporting brain cells to dehydrocostus lactone for 24 hours reduced their harmful effects on nerve cells.In mouse cell experiments, exposing supporting brain cells to dehydrocostus lactone for 24 hours reduced their harmful effects on nerve cells.
Each extra copy was linked to lower odds of cancer history, with an odds ratio of 0.91 compared with one fewer copy.Each extra copy was linked to lower odds of cancer history, with an odds ratio of 0.91 compared with one fewer copy.
Among 37 Mexico City children, 37.8% had Alzheimer- and Parkinson-related brain changes; 32.4% had both plus abnormalities in a third protein.Among 37 Mexico City children, 37.8% had Alzheimer- and Parkinson-related brain changes; 32.4% had both plus abnormalities in a third protein.
