Hippocampal sclerosis

Biomarker

3 papers5 findings

  • Humans3

Associations

5

TDP-43 pathology

upin humans1

1 study
  1. Hippocampal sclerosis predicts TDP-43 pathology in humans (PPV 48.8%).

    “The positive predictive value (PPV) of HS for TDP‐ 43 pathology was 48.8%”

    Humansbrainn = 1,307

    Bridging the Gap: Can Hippocampal Sclerosis Serve as a Surrogate Biomarker for LATE‐NC?

    AAIC 2025 abstract7 Jan 2026

More on TDP-43 pathology

Diabetes mellitus

upin humans1

1 study
  1. Hippocampal sclerosis is associated with diabetes mellitus in humans.

    “and diabetes mellitus ( p = 0.003)”

    Humansbrain

    Bridging the Gap: Can Hippocampal Sclerosis Serve as a Surrogate Biomarker for LATE‐NC?

    AAIC 2025 abstract7 Jan 2026

More on Diabetes mellitus

Lacunar infarcts

upin humans1

1 study
  1. Hippocampal sclerosis is associated with lacunar infarcts in humans.

    “well as lacunar infarcts ( p = 0.031)”

    Humansbrain

    Bridging the Gap: Can Hippocampal Sclerosis Serve as a Surrogate Biomarker for LATE‐NC?

    AAIC 2025 abstract7 Jan 2026

More on Lacunar infarcts

Hyaline arteriolosclerosis

upin humans1

1 study
  1. Hippocampal sclerosis is associated with hyaline arteriolosclerosis in humans.

    “HS was also significantly associated with hyaline arteriolosclerosis ( p = 0.001)”

    Humansbrain

    Bridging the Gap: Can Hippocampal Sclerosis Serve as a Surrogate Biomarker for LATE‐NC?

    AAIC 2025 abstract7 Jan 2026

More on Hyaline arteriolosclerosis

Limbic-predominant age-related TDP-43 encephalopathy neuropathological change

upin humans1

1 study
  1. Hippocampal sclerosis is associated with limbic-predominant age-related TDP-43 encephalopathy neuropathological change in humans.

    “Multivariate analysis confirmed associations between HS and LATE‐NC ( p < 0.001)”

    Humansbrain

    Bridging the Gap: Can Hippocampal Sclerosis Serve as a Surrogate Biomarker for LATE‐NC?

    AAIC 2025 abstract7 Jan 2026

More on Limbic-predominant age-related TDP-43 encephalopathy neuropathological change

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