TDP-43 pathology

Biomarker

1 paper1 finding

Humans1

Associations

TMEM106B

upin humans1

1 study

TMEM106B is associated with TDP-43 pathology in humans.
Humansbrainn = 1,299
TMEM106B haplotypes show distinct associations with tau and TDP-43 pathologies in the aging brain
medRxiv12 Aug 2026Preprint

Latest

4 in 12 months

bioRxiv2 Oct

Single-neuron sequencing reveals widespread low-frequency somatic mutations in dementia brains

Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.

Preprint: case-control study in peopleMechanisms

Paper

Movement Disorders28 Sep

Lewy body disease tracks with cognitive decline and psychosis

Lewy body disease prevalence rose from 0.7% in individuals younger than 50 to 20.0% in those aged 90 and older across 2,480 autopsied human brains.Lewy body disease prevalence rose from 0.7% in individuals younger than 50 to 20.0% in those aged 90 and older across 2,480 autopsied human brains.

Cohort study of 2,480 peoplePopulations

Paper

bioRxiv30 Aug