Skin inflammation

2 papers2 findings

Animals2

Interventions

1

Nicotinamide mononucleotide

downin mice1

1 study

Nicotinamide mononucleotide decreases skin inflammation in mice.
“NAD+ repletion by transdermal supplementation of nicotinamide mononucleotide (NMN) suppressed the rise of IL-36 levels and skin inflammation.”
Animalsin epidermis-specific Nampt-conditional KO miceskin
Epidermal NAD+ deficiency induces IL-36-mediated skin inflammation and acanthosis
JCI insight10 Feb 2026

More on Nicotinamide mononucleotide

Upstream

1

NAMPT

downin mice1

1 study

NAMPT prevents skin inflammation in mice.
“Consequently, Nampt-cKO mice developed spontaneous skin inflammation and epidermal hyperplasia.”
Animalsin epidermis-specific Nampt-conditional KO miceskin
Epidermal NAD+ deficiency induces IL-36-mediated skin inflammation and acanthosis
JCI insight10 Feb 2026

Trial sponsors

Wei-Che Ko
1 trialPhase 2/345 people

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5 in 12 months

EBioMedicine22 Sep

Age-related changes of FCGR3A⁺ natural killer cells and their association with elderly atopic dermatitis

Cohort study in peopleMechanisms

The Journal of Investigative Dermatology9 Sep

Aging-related IgG accumulation promotes skin inflammation

Experiments in miceInflammation

Immunity & Ageing1 Aug

Cellular senescence: the "hidden driver" in chronic inflammatory skin disorders

ReviewCellular senescence

bioRxiv30 Apr

Fibroblast-encoded inflammatory memory orchestrates recurrent skin inflammation via NNMT-dependent metabolic remodeling

Preprint: experiments in miceMethionine and one-carbon metabolism

JCI Insight10 Feb

Epidermal NAD+ deficiency induces IL-36-mediated skin inflammation and acanthosis

Experiments in miceSkin

Frontiers in Bioengineering and Biotechnology7 Mar

Low-temperature cold plasma promotes wound healing by inhibiting skin inflammation and improving skin microbiome

Experiments in animalsInterventions

Disease Models & Mechanisms2 Jan

Dose-dependent effects of Nrf2 on the epidermis in chronic skin inflammation

Experiments in animalsMechanisms

International Immunopharmacology18 Sep

Topical administration of a BCL-2 inhibitor alleviates cutaneous lupus erythematosus

Experiments in animalsInterventions

Experimental Dermatology22 Aug

Skin inflammatory signatures, as measured by disordered spatial redness patterns, predict current and future skin ageing attributes

Study in peopleBiomarkers

Journal of Dermatological Science27 Jun

RAS-activated PI3K/AKT signaling sustains cellular senescence via P53/P21 axis in experimental models of psoriasis

Study in peopleMechanisms