H3K27me3
Biomarker1 paper1 finding
- Cells1
Interventions
1DNMT3A mutation
downin human cells1
1 study
DNMT3A mutation
downin human cells1
DNMT3A mutation decreases H3K27me3 in human cells.
Cellsmacrophage
DNMT3A mutations linked to clonal hematopoiesis alter macrophage epigenetics and accelerate migration · bioRxiv · 25 Sep 2026 · Preprint
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DNMT3A mutations linked to clonal hematopoiesis alter macrophage epigenetics and accelerate migration
The mutations derepress Polycomb target genes at specific chromatin sites and prompt earlier macrophage recruitment to injured tissues.