IL-36

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Nicotinamide mononucleotide

downin mice1

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Nicotinamide mononucleotide decreases IL-36 in mice.
“NAD+ repletion by transdermal supplementation of nicotinamide mononucleotide (NMN) suppressed the rise of IL-36 levels and skin inflammation.”
Animalsin epidermis-specific Nampt-conditional KO miceskin
Epidermal NAD+ deficiency induces IL-36-mediated skin inflammation and acanthosis
JCI insight10 Feb 2026

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