What does the research say about renovascular hypertension?

Renovascular hypertension

There are 9 papers on renovascular hypertension in aging research: 2 trials and 1 observational study in people, 6 in animals. The newest story, Oct 20, 2026: “Kidney-related high blood pressure damaged white matter in rats”.

Disease

9 papers study it3 more mention it2 findings

1 new paper in 30 daysSee all 12 papers on renovascular hypertension

“p16+/uromodulin+ in renovascular hypertension versus EH”

Senescent Kidney Cells in Hypertensive Patients Release Urinary Extracellular VesiclesJournal of the American Heart Association2019doi:10.1161/jaha.119.012584

Human trial2
Humans1
Animals6

Effects

p21+ urinary exosomes

upin humans1

1 study

Renovascular hypertension is linked with higher p21+ urinary exosomes in humans (compared with healthy volunteers).
“in human RVH, p21+ urinary exosomes were elevated compared to HV”
Humanscompared with healthy volunteersurine
Increased cellular senescence in the murine and human stenotic kidney: Effect of mesenchymal stem cells
Journal of cellular physiologyJul 13, 2020

Associations

p16+/uromodulin+ extracellular vesicles

upin humans1

1 study

Renovascular hypertension is associated with p16+/uromodulin+ extracellular vesicles in humans (renovascular hypertension versus essential hypertension).
“p16+/uromodulin+ in renovascular hypertension versus EH”
Humansrenovascular hypertension versus essential hypertensionascending limb of Henle's loopn = 14
Senescent Kidney Cells in Hypertensive Patients Release Urinary Extracellular Vesicles
Journal of the American Heart AssociationJun 1, 2019

More on p16+/uromodulin+ extracellular vesicles

Trial sponsors

Stealth BioTherapeutics
Company1 trialPhase 1/216 people
University of Aarhus
1 trial80 people

Latest

2 papers in 12 months

medRxivOct 20

Kidney-related high blood pressure damaged white matter in rats

About two-thirds of rats with kidney-related high blood pressure developed white matter lesions, which expanded between seven and nine weeks.About two-thirds of rats with kidney-related high blood pressure developed white matter lesions, which expanded between seven and nine weeks.

Preprint: rat study · 13 ratsKidney