Prevalent cardiovascular disease

1. Triglyceride-glucose index was not clearly linked with prevalent cardiovascular disease in humans (Overweight or obesity; fully adjusted model).

   “TyG was not significantly associated with ACM, CVM, or prevalent CVD after full adjustment.”

   HumansOverweight or obesity; fully adjusted modeln = 6,443

   Independent and Joint Associations of the Planetary Health Diet Index and Triglyceride‐Glucose Index With Mortality and Prevalent Cardiovascular Disease in Adults With Overweight or Obesity: <scp>NHANES</scp> 2005–2018

   FASEB journal : official publication of the Federation of American Societies for Experimental Biology·Nov 11, 2026

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1. TyG-Sarcopenia Index predicts prevalent cardiovascular disease in humans (single-indicator discrimination) (AUC 0.580 for prevalent CVD; 0.579 for heart disease; 0.577 for stroke).

   “Single-indicator AUCs were 0.580, 0.579, and 0.577 for prevalent CVD, heart disease, and stroke”

   Humanssingle-indicator discriminationn = 10,266

   Beyond lipids: sarcopenia as a cardiovascular risk indicator in Chinese middle-aged and older adults

   Cardiovascular diabetology·Oct 23, 2026

2. TyG-Sarcopenia Index is associated with prevalent cardiovascular disease in humans (Q4 versus Q1; multivariable-adjusted) (OR 1.36, 95% CI 1.15–1.60, Q4 versus Q1).

   “prevalence rose across TyG-SI quartiles from 14.4% to 26.3% ( P for trend < 0.001), with an odds ratio of 1.36 (95% CI 1.15–1.60)”

   HumansQ4 versus Q1; multivariable-adjustedn = 10,266

   Beyond lipids: sarcopenia as a cardiovascular risk indicator in Chinese middle-aged and older adults

   Cardiovascular diabetology·Oct 23, 2026

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1. Planetary Health Diet Index is associated with prevalent cardiovascular disease in humans (Overweight or obesity; highest versus lowest PHDI quartile; fully adjusted model) (OR 0.60, 95% CI 0.45–0.81).

   “The highest PHDI quartile was also associated with lower odds of prevalent CVD (OR = 0.60, 95% CI: 0.45–0.81)”

   HumansOverweight or obesity; highest versus lowest PHDI quartile; fully adjusted modeln = 6,443

   Independent and Joint Associations of the Planetary Health Diet Index and Triglyceride‐Glucose Index With Mortality and Prevalent Cardiovascular Disease in Adults With Overweight or Obesity: <scp>NHANES</scp> 2005–2018

   FASEB journal : official publication of the Federation of American Societies for Experimental Biology·Nov 11, 2026

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1. Socioeconomic status is associated with prevalent cardiovascular disease in humans (OR 0.80, 95% CI 0.75–0.85).

   “Higher SES was associated with lower odds of prevalent CVD (OR 0.80, 95% CI 0.75–0.85; p < 0.001)”

   Humansn = 4,772

   Upstream behavioural and biological contributions to socioeconomic disparities in cardiovascular disease

   Public health·Nov 10, 2026

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1. Skeletal muscle-fat distribution metabolic index is associated with prevalent cardiovascular disease in humans (cross-sectional analysis).

   “The cross-sectional analysis also showed an inverse association with prevalent CVD.”

   Humanscross-sectional analysisn = 8,279

   Association Between Skeletal Muscle-Fat Distribution Metabolic Index and Cardiovascular Disease: A Cohort Study

   Metabolites·Nov 9, 2026

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1. Renal-proteinuric-anemia phenotype is associated with prevalent cardiovascular disease in humans (Class 2 compared with the relatively preserved biomarker phenotype; adjusted analysis).

   “Class 2 was associated with higher odds of prevalent clinical cardiovascular disease (adjusted odds ratio 1.98 [1.22-3.20]) and frailty (2.31 [1.69-3.16]).”

   HumansClass 2 compared with the relatively preserved biomarker phenotype; adjusted analysisn = 2,248

   Latent Biomarker Phenotypes in Older Adults Identify Distinct Patterns of Frailty, Cardiovascular Disease, and Mortality Risk

   AHA Scientific Sessions 2026 abstract·Nov 2, 2026

1. C-reactive protein is associated with prevalent cardiovascular disease in humans (LDL-C <100 mg/dL; adjusted for age, BMI, diabetes status, and sex) (OR 1.11 per doubling, 95% CI 1.01–1.23).

   “each doubling of hs-CRP was associated with higher odds of prevalent CVD (OR 1.11, 95% CI 1.01-1.23; p < 0.05).”

   HumansLDL-C <100 mg/dL; adjusted for age, BMI, diabetes status, and sexeach doubling of hs-CRPn = 2,457

   Inflammatory Cardiovascular Risk and Statin Use Among U.S. Adults with Normal LDL Cholesterol

   AHA Scientific Sessions 2026 abstract·Nov 2, 2026

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1. Triglyceride-glucose-frailty index is associated with prevalent cardiovascular disease in humans (OR 4.50, 95% CI 3.20–6.33 per 1-unit higher TyG-FI).

   “each 1-unit higher TyG-FI was associated with higher odds of prevalent CVD (odds ratio, 4.50; 95% confidence interval, 3.20-6.33)”

   HumansUS adults with self-reported rheumatoid arthritis; fully adjusted models; per 1-unit higher TyG-FIn = 1,090

   Comparison analysis of the triglyceride-glucose index, triglyceride-glucose and frailty index in cardiovascular disease and mortality association among patients with rheumatoid arthritis: A population-based cohort study

   Medicine·Oct 16, 2026

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1. hybrid machine learning framework predicts prevalent cardiovascular disease in silico (independent external validation cohort) (accuracy 70–74%; AUC 0.82–0.85).

   “On the external cohort the six pipelines performed comparably (accuracy 70-74%, external-cohort AUC 0.82-0.85)”

   In silicoindependent external validation cohortn = 219

   Machine Learning Approach for Cardiovascular Disease Risk Stratification Using Ensemble Classifiers and Dimensionality Reduction

   Life (Basel, Switzerland)·Oct 15, 2026