Triglyceride-glucose-frailty index

Biomarker2 papers8 findings

One human study links a higher triglyceride-glucose-frailty index to mortality, cardiovascular death, cardiometabolic multimorbidity and cardiovascular-kidney-metabolic syndrome. Another human study associates it with greater risks of cognitive impairment and depression and reports predictive performance for both.

Humans2

Associations

6

Cognitive impairment

upin humans1OR 1.51

1 study

Triglyceride-glucose-frailty index predicts cognitive impairment in humans (AUC of 0.634).
Humans
Predictive Value of the Triglyceride-Glucose-Frailty Index for Depression and Cognitive Function in Perimenopausal Women: Insights from CHARLS · International journal of women's health · 4 Sep 2026
Triglyceride-glucose-frailty index raises the risk of cognitive impairment in humans (OR = 1.51, 95% CI: 1.34-1.71).
Humansfully adjusted model
Predictive Value of the Triglyceride-Glucose-Frailty Index for Depression and Cognitive Function in Perimenopausal Women: Insights from CHARLS · International journal of women's health · 4 Sep 2026

Cognitive impairment →

Depression

upin humans1OR 3.7

1 study

Triglyceride-glucose-frailty index predicts depression in humans (AUC of 0.786).
Humans
Predictive Value of the Triglyceride-Glucose-Frailty Index for Depression and Cognitive Function in Perimenopausal Women: Insights from CHARLS · International journal of women's health · 4 Sep 2026
Triglyceride-glucose-frailty index raises the risk of depression in humans (OR = 3.70, 95% CI: 3.18-4.32).
Humansfully adjusted model
Predictive Value of the Triglyceride-Glucose-Frailty Index for Depression and Cognitive Function in Perimenopausal Women: Insights from CHARLS · International journal of women's health · 4 Sep 2026

Cardiovascular death

upin humans1HR 5.82

1 study

Triglyceride-glucose-frailty index raises the risk of cardiovascular death in humans (HR = 5.82, 95% CI: 3.38-10.03).
Humanshighest vs lowest quartilemedian 90 monthsn = 11,228
Evaluative performance of triglyceride-glucose-frailty index versus surrogate insulin resistance indices for advanced cardiovascular-kidney-metabolic syndrome, cardiometabolic multimorbidity, and mortality: the role of estimated glomerular filtration rate · Cardiovascular diabetology · 3 Sep 2026

Mortality

upin humans1HR 3.9

1 study

Triglyceride-glucose-frailty index raises the risk of mortality in humans (HR = 3.90, 95% CI: 2.96-5.13).
Humanshighest vs lowest quartilemedian 90 monthsn = 11,228
Evaluative performance of triglyceride-glucose-frailty index versus surrogate insulin resistance indices for advanced cardiovascular-kidney-metabolic syndrome, cardiometabolic multimorbidity, and mortality: the role of estimated glomerular filtration rate · Cardiovascular diabetology · 3 Sep 2026

Cardiometabolic multimorbidity

upin humans1OR 5.09

1 study

Triglyceride-glucose-frailty index is associated with cardiometabolic multimorbidity in humans (OR = 5.09, 95% CI: 2.83-9.16).
Humanshighest vs lowest quartilen = 11,228
Evaluative performance of triglyceride-glucose-frailty index versus surrogate insulin resistance indices for advanced cardiovascular-kidney-metabolic syndrome, cardiometabolic multimorbidity, and mortality: the role of estimated glomerular filtration rate · Cardiovascular diabetology · 3 Sep 2026

Cardiometabolic multimorbidity →

Cardiovascular-kidney-metabolic syndrome

upin humans1OR 4.57

1 study

Triglyceride-glucose-frailty index is associated with cardiovascular-kidney-metabolic syndrome in humans (OR = 4.57, 95% CI: 3.50-5.99).
Humanshighest vs lowest quartilen = 11,228
Evaluative performance of triglyceride-glucose-frailty index versus surrogate insulin resistance indices for advanced cardiovascular-kidney-metabolic syndrome, cardiometabolic multimorbidity, and mortality: the role of estimated glomerular filtration rate · Cardiovascular diabetology · 3 Sep 2026

Cardiovascular-kidney-metabolic syndrome →

Latest

2

International Journal of Women's HealthHumans10 Sep

Predictive Value of the Triglyceride-Glucose-Frailty Index for Depression and Cognitive Function in Perimenopausal Women: Insights from CHARLS

Cardiovascular DiabetologyHumans4 Sep

Evaluative performance of triglyceride-glucose-frailty index versus surrogate insulin resistance indices for advanced cardiovascular-kidney-metabolic syndrome, cardiometabolic multimorbidity, and mortality: the role of estimated glomerular filtration rate