TyG-Sarcopenia Index

1. TyG-Sarcopenia Index predicts prevalent cardiovascular disease in humans (single-indicator discrimination) (AUC 0.580 for prevalent CVD; 0.579 for heart disease; 0.577 for stroke).

   “Single-indicator AUCs were 0.580, 0.579, and 0.577 for prevalent CVD, heart disease, and stroke”

   Humanssingle-indicator discriminationn = 10,266

   Beyond lipids: sarcopenia as a cardiovascular risk indicator in Chinese middle-aged and older adults

   Cardiovascular diabetology·Oct 23, 2026

2. TyG-Sarcopenia Index is associated with prevalent cardiovascular disease in humans (Q4 versus Q1; multivariable-adjusted) (OR 1.36, 95% CI 1.15–1.60, Q4 versus Q1).

   “prevalence rose across TyG-SI quartiles from 14.4% to 26.3% ( P for trend < 0.001), with an odds ratio of 1.36 (95% CI 1.15–1.60)”

   HumansQ4 versus Q1; multivariable-adjustedn = 10,266

   Beyond lipids: sarcopenia as a cardiovascular risk indicator in Chinese middle-aged and older adults

   Cardiovascular diabetology·Oct 23, 2026

More on Prevalent cardiovascular disease

1. TyG-Sarcopenia Index is associated with incident cardiovascular disease in humans (baseline CVD-free adults; per SD higher TyG-SI; multivariable-adjusted) (HR 1.14, 95% CI 1.06–1.22 per SD higher TyG-SI).

   “per SD higher TyG-SI, the adjusted hazard ratio was 1.14 (95% CI 1.06–1.22) for incident CVD.”

   Humansbaseline CVD-free adults; per SD higher TyG-SI; multivariable-adjustedapproximately 5 yearsn = 6,934

   Beyond lipids: sarcopenia as a cardiovascular risk indicator in Chinese middle-aged and older adults

   Cardiovascular diabetology·Oct 23, 2026

More on Incident cardiovascular disease