Posttraumatic osteoarthritis

10 papers study it8 more mention it2 findings

Human trial1
Humans2
Animals5
In silico1

Upstream

1

Senescent cells

upin mice1

1 study

Senescent cells increase posttraumatic osteoarthritis in mice.
“local limitation of the detrimental roles of SnCs can attenuate the development of posttraumatic OA”
Animalslocal limitation via intra-articular ganciclovirjoint
TGF-β/Alk5 signaling prevents osteoarthritis initiation via regulating the senescence of articular cartilage stem cells
Journal of cellular physiologyJan 16, 2021

More on Senescent cells

Associations

1

Cellular senescence

upin humans1

1 study

Posttraumatic osteoarthritis is associated with cellular senescence in humans.
“We also provide clinical evidence of elevated senescent cell burden in the muscle of patients following ACL injury and with PTOA”
Humansafter ACL injury and with PTOAskeletal muscle
Cellular senescence links muscle atrophy and posttraumatic osteoarthritis after ACL injury
Function (Oxford, England)Jun 25, 2026

More on Cellular senescence

Funding

1 grant since 2017

National Institute of Arthritis and Musculoskeletal and Skin DiseasesUS$498k

Genetic and Molecular Insights into Cartilage Regeneration, Primary and Posttraumatic Osteoarthritis
National Institute of Arthritis and Musculoskeletal and Skin DiseasesWashington UniversityUS$249k2017–2020

Latest

2 papers in 12 months

FunctionJun 26

Cellular senescence links muscle atrophy and posttraumatic osteoarthritis after ACL injury

Study in peopleBones and joints

The Journal of ArthroplastyOct 18

To Fix or Replace? A Systematic Review and Meta-Analysis on Surgical Management of Acetabular Fractures in the Elderly

Meta-analysis of observational studiesBones and joints

MedicineOct 15

Is there any difference between open reduction and internal fixation vs combined hip procedure after geriatric acetabular fracture?: A randomized controlled trial

Randomized trial in 24 peopleBones and joints

JCI InsightDec 24

TRPC1 links calcium signaling to cellular senescence in the protection against posttraumatic osteoarthritis

Experiments in miceCellular senescence

Osteoarthritis and CartilageApr 28

Deletion of the chondrocyte glucocorticoid receptor attenuates cartilage degradation through suppression of early synovial activation in murine posttraumatic osteoarthritis

Experiments in miceBones and joints

European Journal of Trauma and Emergency SurgeryMar 6

Total elbow arthroplasty in elderly trauma patients: adding a new perspective for functional evaluation

Cohort study in peopleTrauma

The Journals of Gerontology, Series AJan 4

Meta-analysis Integrated With Multi-omics Data Analysis to Elucidate Pathogenic Mechanisms of Age-Related Knee Osteoarthritis in Mice

Computational studyBones and joints

Journal of Cellular PhysiologyJan 17

TGF-β/Alk5 signaling prevents osteoarthritis initiation via regulating the senescence of articular cartilage stem cells

Experiments in miceTGF-β signaling

The Journal of Clinical InvestigationSep 22

IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis

Experiments in miceOsteoarthritis

Osteoarthritis and CartilageAug 13

Compromised autophagy precedes meniscus degeneration and cartilage damage in mice

Experiments in miceBones and joints