Plasma cell neoplasm

1. RRM2B protects against plasma cell neoplasm in mice (30%-40%).

   “30%-40% of aged Rrm2b heterozygous knockout mice developed plasma cell neoplasms”

   Animalsheterozygous knockout

   Chromosomal instability triggered by Rrm2b loss leads to IL-6 secretion and plasmacytic neoplasms

   Cell reports·2 May 2013

More on RRM2B

1. Caloric restriction raises the risk of plasma cell neoplasm in mice (66% vs 41%).

   “The incidence of the most prevalent cancer, plasma cell neoplasm, was higher in RD mice (66%) than in ND mice (41%).”

   Animalsfrom middle agemalesn = 300

   Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice

   Cancer research·1 Apr 1999

More on Caloric restriction