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RRM2B

Gene

1 paper1 finding

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 2 countries
  • Funders: Lymphoma Research Foundation and 1 more
  • Animals1

Effects

1

Plasma cell neoplasm

downin mice1

1 study

  1. RRM2B protects against plasma cell neoplasm in mice (30%-40%).

    “30%-40% of aged Rrm2b heterozygous knockout mice developed plasma cell neoplasms”

    Animalsheterozygous knockout

    Chromosomal instability triggered by Rrm2b loss leads to IL-6 secretion and plasmacytic neoplasms

    Cell reports2 May 2013

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