Spermidine decreases osteoarthritis progression in mice.
“Exogenous supplementation with SPD via a ROS-responsive SH@LNP@SPD hydrogel alleviated OA progression by promoting M2c macrophage polarization in vivo.”
A slow-release spermidine gel reduced disease progression in mice with surgically induced osteoarthritis, while shifting immune cells toward a beneficial state.A slow-release spermidine gel reduced disease progression in mice with surgically induced osteoarthritis, while shifting immune cells toward a beneficial state.