Osteoarthritis progression

Disease

2 papers study it72 more mention it2 findings

  • Animals2

Interventions

2

Spermidine

downin mice1

1 study
  1. Spermidine decreases osteoarthritis progression in mice.

    “Exogenous supplementation with SPD via a ROS-responsive SH@LNP@SPD hydrogel alleviated OA progression by promoting M2c macrophage polarization in vivo.”

    Animalssurgically induced osteoarthritisROS-responsive SH@LNP@SPD hydrogel

    Spermidine gel slowed osteoarthritis progression in mice

    Journal of nanobiotechnology

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miR-140-5P-LOADED hydrogel

downin rats1

1 study
  1. miR-140-5P-LOADED hydrogel decreases osteoarthritis progression in rats.

    “the hydrogel attenuated chondrocyte senescence and OA progression in an aged rat model”

    Animalsosteoarthritisinjectable bioadhesive and lubricating hydrogel containing polyphenol-armored nanoparticlesjoint

    Bioadhesive Hydrogel With Polyphenol-Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

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Funding

3 grants since 2025

Japan Society for the Promotion of ScienceJP¥8.8mNatural Science Foundation of Hunan Province

Latest

Nov 2025: 2Dec 2025: 1Jan 2026: 4Feb 2026: 4Mar 2026: 3Apr 2026: 4May 2026: 1Jun 2026: 3Jul 2026: 2Aug 2026: 2Sep 2026: 1Oct 2026: 027 papers in 12 months
Journal of Nanobiotechnology

Spermidine gel slowed osteoarthritis progression in mice

A slow-release spermidine gel reduced disease progression in mice with surgically induced osteoarthritis, while shifting immune cells toward a beneficial state.A slow-release spermidine gel reduced disease progression in mice with surgically induced osteoarthritis, while shifting immune cells toward a beneficial state.

Mouse studySpermidine