1 paper1 finding
CKD polygenic risk score
upin humans1
CKD polygenic risk score predicts kidney disease progression in humans (aHR 1.17 (95% CI, 1.10-1.26)).
“the PRS was independently associated with an aHR (per 1-SD) for the composite renal outcome of 1.17 (95% CI, 1.10-1.26, p<0.001).”
Humans2.5 yearsn = 35,182
AHA Scientific Sessions 2025 abstract3 Nov 2025
The two-year combined outcome rate was 15.6% for sodium-glucose cotransporter 2 inhibitors versus 19.9% for renin-angiotensin system inhibitors, the comparison drug…The two-year combined outcome rate was 15.6% for sodium-glucose cotransporter 2 inhibitors versus 19.9% for renin-angiotensin system inhibitors, the comparison drug class.
Adding a GLP-1 receptor agonist was linked to lower rates of major adverse kidney events (HR 0.70) compared with SGLT2 inhibitor monotherapy over 12 months.Adding a GLP-1 receptor agonist was linked to lower rates of major adverse kidney events (HR 0.70) compared with SGLT2 inhibitor monotherapy over 12 months.