MechanismsReview

Necroptosis-senescence crosstalk in tubulointerstitial fibrosis: the mtDNA-cGAS-STING-PFKFB3 axis as a metabolic bridge

Graphical abstract. The central hypothesis: mtDNA–cGAS–STING–PFKFB3–glycolysis axis.
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Graphical abstract. The central hypothesis: mtDNA–cGAS–STING–PFKFB3–glycolysis axis.The central hypothesis: mtDNA–cGAS–STING–PFKFB3–glycolysis axis.Wang et al.

Frontiers in Medicine

The paper

Wang D, Zheng H, Zhang X et al.

Frontiers in Medicine · 3 Sep 2026

doi.org/10.3389/fmed.2026.1882589PubMed 42755616

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