NAD+
Biomarker4 papers4 findings
- Animals1
- Cells1
Interventions
3Nicotinamide mononucleotide
upin humans1
1 study
Nicotinamide mononucleotide
upin humans1
Nicotinamide mononucleotide increases NAD+ in humans.
“Short-term IV NAD + or NMN administration has been associated with transient increases in circulating NAD + levels”
Reviewshort-term IV administrationintravenous
Narrative review of intravenous NAD⁺ and NAD⁺ precursors in wellness and translational medicine · Frontiers in aging · 10 Sep 2026
NAD+
upin humans1
1 study
NAD+
upin humans1
NAD+ increases NAD+ in humans.
“Short-term IV NAD + or NMN administration has been associated with transient increases in circulating NAD + levels”
Reviewshort-term IV administrationintravenous
Narrative review of intravenous NAD⁺ and NAD⁺ precursors in wellness and translational medicine · Frontiers in aging · 10 Sep 2026
Nampt knockdown
downin human cells1
1 study
Nampt knockdown
downin human cells1
Nampt knockdown decreases NAD+ in human cells.
CellssiRNAnucleus pulposus cell
Mechanism of the NAMPT-SIRT2-Lactate Axis in Senescence of Human Nucleus Pulposus Cells · Frontiers in bioscience (Landmark edition) · 1 Sep 2026
Upstream
1CD38
downin cells1
1 study
CD38
downin cells1
CD38 decreases NAD+ in cells.
Cellsdecidual stromal cell
Macrophage CD38 drives age-related placental senescence by depleting NAD+ · Nature communications · 27 Aug 2026
Latest
4Mechanism of the NAMPT-SIRT2-Lactate Axis in Senescence of Human Nucleus Pulposus Cells
Macrophage CD38 drives age-related placental senescence by depleting NAD+
Targeting CD38 or supplementing NAD+ precursors reduces placental aging and improves offspring metabolic health in models of delayed maternal age.
Nature communications · Hua L et al.