What does the research say about Depression-like behavior?

Depression-like behavior

There are 5 papers on depression-like behavior in aging research: none in people yet, 5 in animals. The newest story, Oct 4, 2026: “TRPM3 inhibition reverses depressive behaviors in rats”.

Disease

5 papers study it74 more mention it1 finding

3 new papers in 30 daysSee all 79

Animals5

Upstream

Age

upin mice1

1 study

Age increases depression-like behavior in mice (SAMP8 mice at 17 weeks versus 8 weeks of age).
“SAMP8 mice at 17 weeks, but not 8 weeks, exhibited anxiety- and depression-like behaviors”
AnimalsSAMP8 mice at 17 weeks versus 8 weeks of age
Neuroinflammaging underlies emotional disturbances and circadian rhythm disruption in young male senescence-accelerated mouse prone 8 mice
Experimental gerontologyOct 16, 2020

Latest

19 papers in 12 months

Aging CellMay 26

Brain estrogen loss linked to memory problems in old female mice

Experiments in mice aged 6 to 8 months and over 19 months linked low brain estrogen to memory difficulties and altered gene activity in older females.Experiments in mice aged 6 to 8 months and over 19 months linked low brain estrogen to memory difficulties and altered gene activity in older females.

Mouse studyMechanisms

Paper

Sleep ScienceOct 20

Effect of Long-Term Physical Exercise on Memory, Anxiety-Like Behavior, and Depression in Young and Aged Male Mice Subjected to Sleep Deprivation

Experiments in miceAerobic exercise

Paper

Journal of Cellular BiochemistryOct 6

Chronic stress worsened bone loss in mice after ovary removal

In an animal experiment, mice whose ovaries had been removed showed worse osteoporosis and anxiety- and depression-like behavior after eight weeks of chronic stress.In an animal experiment, mice whose ovaries had been removed showed worse osteoporosis and anxiety- and depression-like behavior after eight weeks of chronic stress.

Experiments in miceBones and joints

Paper

The Journal of Pharmacology and Experimental TherapeuticsOct 2

TRPM3 inhibition reverses depressive behaviors in rats

In ovariectomized rats, inhibiting TRPM3 with naringenin restored serotonin signaling and dendritic arborization while reducing neuroinflammation and depressive-like…In ovariectomized rats, inhibiting TRPM3 with naringenin restored serotonin signaling and dendritic arborization while reducing neuroinflammation and depressive-like deficits.

Experiments in ratsMechanisms

Paper

Journal of EthnopharmacologySep 4