AgingResearch.NewsJoin free

Coronary artery disease risk

Papers on coronary artery disease risk

39 papers9 new in 30 days

Monday, November 9

AHA Scientific Sessions 2026 Abstract

Activity’s link to lower coronary disease risk varies by sex

The highest activity category had a pooled hazard ratio of 0.47 versus the lowest, a measure of relative coronary artery disease risk over follow-up.The highest activity category had a pooled hazard ratio of 0.47 versus the lowest, a measure of relative coronary artery disease risk over follow-up.

A heart with branching coronary arteries is surrounded by running and standing people and artery sections with open or plaque-narrowed passages.
Cohort · 120,369 peoplePopulations
Paper

Saturday, November 7

AHA Scientific Sessions 2026 Abstract

AI model outperformed heart disease risk tools in US records

The model outperformed conventional methods, with one-year scores of 0.946 in TriNetX and 0.945 in eMERGE for distinguishing future cases from noncases.The model outperformed conventional methods, with one-year scores of 0.946 in TriNetX and 0.945 in eMERGE for distinguishing future cases from noncases.

Coronary artery cross-sections show thick plaque narrowing one opening and little plaque in the other, with small groups of people beneath them.
Computational studyBiomarkers
Paper
AHA Scientific Sessions 2026 Abstract

A blood particle’s heart disease link is similar across ancestries

Coronary artery disease odds were about 1.07 times as high per doubling of genetically estimated lipoprotein(a), a fat-carrying blood particle.Coronary artery disease odds were about 1.07 times as high per doubling of genetically estimated lipoprotein(a), a fat-carrying blood particle.

Coronary artery cross-sections show more plaque beside dense blood particles and less plaque beside sparse particles, with groups of people nearby.
Cohort · 657,692 peopleBiomarkers
Paper

Thursday, November 5

Circulation Genomic and Precision Medicine

New score better flags hidden artery disease in low-risk adults

Independent testing found better discrimination of artery calcium warranting clinical attention, with scores of 0.67 for the new model versus 0.55 for a traditional risk…Independent testing found better discrimination of artery calcium warranting clinical attention, with scores of 0.67 for the new model versus 0.55 for a traditional risk score.

A cut-open coronary artery shows clustered calcium deposits along one wall and smooth tissue opposite, with blood cells and small molecules nearby.
Cross-sectional · 311 peopleBiomarkers
Paper

Monday, October 26

ESC Congress 2026 Abstract

Two blood fat carriers share protein links to heart disease

Protein patterns accounted for an estimated 62% of coronary disease risk linked to triglyceride-rich particles and 14% of risk linked to lipoprotein(a).Protein patterns accounted for an estimated 62% of coronary disease risk linked to triglyceride-rich particles and 14% of risk linked to lipoprotein(a).

A coronary artery cross-section has a thickened wall crowded with immune cells and proteins, surrounded by fat-carrying particles with similar proteins.
Cohort · 35,269 peopleMechanisms
Paper
ESC Congress 2026 Abstract

A liver protein is linked to coronary artery disease risk

In an analysis of 278 patients with heart disease and biobank data, genetic regulation of a liver-derived protein was associated with higher artery disease risk.In an analysis of 278 patients with heart disease and biobank data, genetic regulation of a liver-derived protein was associated with higher artery disease risk.

A coronary artery narrowed by plaque holds dense protein clusters beside a liver and a smaller, open artery with fewer proteins.
Mendelian randomization · 278 peopleMechanisms
Paper

Thursday, October 8

Fundamental Research

Healthy habits may curb heart risk linked to blood mutations

Blood cell mutations were linked to 41% higher heart disease risk, but an elevated risk was not found in those with a favorable lifestyle.Blood cell mutations were linked to 41% higher heart disease risk, but an elevated risk was not found in those with a favorable lifestyle.

Figure from Fundamental Research
Cohort study of 6,113 peoplePopulations
Paper

Saturday, September 19

Friday, September 4

Nature Cardiovascular Research

Combined gene variants linked to lower coronary artery disease risk

Carrying variants in two genes together was linked to an odds ratio of 0.73 for coronary artery disease compared with noncarriers.Carrying variants in two genes together was linked to an odds ratio of 0.73 for coronary artery disease compared with noncarriers.

Study overview.
Genetic association · 408,039 peopleMechanisms
Paper

Tuesday, September 1

Circulation

Screen in cells may help classify cholesterol gene variants

Combined evidence suggested 322 of 434 gene variants with uncertain, conflicting or missing classifications could qualify for reclassification, pending expert review.Combined evidence suggested 322 of 434 gene variants with uncertain, conflicting or missing classifications could qualify for reclassification, pending expert review.

Activity-normalized prime editing screening (ANPE) pipeline and benchmarking.
Human cell studyLDL cholesterol
Paper

Thursday, August 27

Thursday, August 20

Friday, July 31

Sunday, June 7

Wednesday, May 20

Sunday, March 29

Friday, March 27

Wednesday, March 18

Thursday, February 19

Friday, February 13

Wednesday, February 11

Thursday, February 5

Monday, November 3