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Coronary artery disease risk

There are 2 papers on coronary artery disease risk in aging research: 2 observational studies in people. The newest story, Oct 26, 2026: “A liver protein is linked to coronary artery disease risk”.

Disease

2 papers study it37 more mention it3 findings

9 new papers in 30 daysSee all 39 papers on coronary artery disease risk

“In multivariable Mendelian randomization, the impact of eGenes on the lifespan potential was mediated by the CAD risk.”
System Genetics Including Causal Inference Identify Immune Targets for Coronary Artery Disease and the LifespanCirculation. Genomic and precision medicine2021doi:10.1161/circgen.120.003196
  • Humans2

Effects

1

Lifespan

mediatesin humans1

1 study

  1. Coronary artery disease risk is linked with lifespan in humans (mediating the impact of 6 eGenes on lifespan potential).

    “In multivariable Mendelian randomization, the impact of eGenes on the lifespan potential was mediated by the CAD risk.”

    Humansmediating the impact of 6 eGenes on lifespan potential

    System Genetics Including Causal Inference Identify Immune Targets for Coronary Artery Disease and the Lifespan

    Circulation. Genomic and precision medicine

Upstream

1

Proteomic markers of immune activation and vascular remodeling

mediatesin humans1

1 study

  1. Proteomic markers of immune activation and vascular remodeling is linked with coronary artery disease risk in humans (TRL-associated risk) (62% mediated).

    “Mediation analysis identified proteomic markers of immune activation and vascular remodeling as primary mediators of TRL-associated CAD risk (proportion mediated: 62%)”

    HumansTRL-associated risk

    Two blood fat carriers share protein links to heart disease

    ESC Congress 2026 abstract

More on Proteomic markers of immune activation and vascular remodeling

Associations

1

Multimodal Transformer

upin silico1

1 study

  1. multimodal Transformer predicts coronary artery disease risk in silico (TriNetX and eMERGE cohorts) (1- and 10-year AUROCs: TriNetX 0.946 (0.944-0.949) and 0.857 (0.851-0.863); eMERGE 0.945 (0.934-0.954) and 0.848 (0.832-0.866)).

    “The multimodal Transformer demonstrated strong performance across cohorts.”

    In silicoTriNetX and eMERGE cohorts1- and 10-year prediction horizons

    AI model outperformed heart disease risk tools in US records

    AHA Scientific Sessions 2026 abstract

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 5Mar 2026: 5Apr 2026: 0May 2026: 1Jun 2026: 1Jul 2026: 2Aug 2026: 1Sep 2026: 3Oct 2026: 3Nov 2026: 627 papers in 12 months
AHA Scientific Sessions 2026 Abstract

AI model outperformed heart disease risk tools in US records

The model outperformed conventional methods, with one-year scores of 0.946 in TriNetX and 0.945 in eMERGE for distinguishing future cases from noncases.The model outperformed conventional methods, with one-year scores of 0.946 in TriNetX and 0.945 in eMERGE for distinguishing future cases from noncases.

Computational studyBiomarkers
Paper
ESC Congress 2026 Abstract

Two blood fat carriers share protein links to heart disease

Protein patterns accounted for an estimated 62% of coronary disease risk linked to triglyceride-rich particles and 14% of risk linked to lipoprotein(a).Protein patterns accounted for an estimated 62% of coronary disease risk linked to triglyceride-rich particles and 14% of risk linked to lipoprotein(a).

Cohort · 35,269 peopleMechanisms
Paper
AHA Scientific Sessions 2026 Abstract

Activity’s link to lower coronary disease risk varies by sex

The highest activity category had a pooled hazard ratio of 0.47 versus the lowest, a measure of relative coronary artery disease risk over follow-up.The highest activity category had a pooled hazard ratio of 0.47 versus the lowest, a measure of relative coronary artery disease risk over follow-up.

Cohort · 120,369 peoplePopulations
Paper
AHA Scientific Sessions 2026 Abstract

A blood particle’s heart disease link is similar across ancestries

Coronary artery disease odds were about 1.07 times as high per doubling of genetically estimated lipoprotein(a), a fat-carrying blood particle.Coronary artery disease odds were about 1.07 times as high per doubling of genetically estimated lipoprotein(a), a fat-carrying blood particle.

Cohort · 657,692 peopleBiomarkers
Paper
Circulation Genomic and Precision Medicine

New score better flags hidden artery disease in low-risk adults

Independent testing found better discrimination of artery calcium warranting clinical attention, with scores of 0.67 for the new model versus 0.55 for a traditional risk…Independent testing found better discrimination of artery calcium warranting clinical attention, with scores of 0.67 for the new model versus 0.55 for a traditional risk score.

Cross-sectional · 311 peopleBiomarkers
Paper
ESC Congress 2026 Abstract

A liver protein is linked to coronary artery disease risk

In an analysis of 278 patients with heart disease and biobank data, genetic regulation of a liver-derived protein was associated with higher artery disease risk.In an analysis of 278 patients with heart disease and biobank data, genetic regulation of a liver-derived protein was associated with higher artery disease risk.

Mendelian randomization · 278 peopleMechanisms
Paper
Fundamental Research

Healthy habits may curb heart risk linked to blood mutations

Blood cell mutations were linked to 41% higher heart disease risk, but an elevated risk was not found in those with a favorable lifestyle.Blood cell mutations were linked to 41% higher heart disease risk, but an elevated risk was not found in those with a favorable lifestyle.

Cohort study of 6,113 peoplePopulations
Paper

See all 39 papers on coronary artery disease risk

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