Journal of Hepatology
Damaged chromosome ends limit liver cell flexibility in mice
Mouse experiments found impaired shifts toward bile duct cells during chronic injury, but no substantial impairment of liver cell survival or basic metabolic function.Mouse experiments found impaired shifts toward bile duct cells during chronic injury, but no substantial impairment of liver cell survival or basic metabolic function.
Mouse studyMechanisms
Who was studiedMice with induced hepatocyte telomere damage
What changedLiver cells with telomere damage were less able to change into bile duct cells during chronic injury
The catchRegeneration after gradual telomere shortening was not measured; telomere breaks were induced