Frontiers in Aging Neuroscience
The novel estrogen receptor beta agonist EGX358 and APOE genotype influence memory, vasomotor, and anxiety outcomes in an Alzheimer's mouse model
Experiments in miceAnxiety
Papers on AD-like pathology
93 papers4 new in 30 days
Wednesday, December 4
Saturday, November 16
Molecular Psychiatry
Gene-dose-dependent reduction of Fshr expression improves spatial memory deficits in Alzheimer's mice
Experiments in animalsMechanisms
Friday, November 1
Neuroscience Bulletin
Neurodegenerative Diseases: What Can Be Learned from Toothed Whales?
ReviewMechanisms
Wednesday, September 25
Free Radical Biology & Medicine
DMT1 knockout abolishes ferroptosis induced mitochondrial dysfunction in C. elegans amyloid β proteotoxicity
Experiments in wormsFerroptosis
Thursday, May 9
Journal of Hazardous Materials
The involvement of SigmaR1K142 degradation mediated by ERAD in neural senescence linked with CdCl₂ exposure
Experiments in miceCellular senescence
Tuesday, December 19
Monday, December 18
Tuesday, October 24
Biomedicine & Pharmacotherapy
SGLT2 and DPP4 inhibitors improve Alzheimer's disease-like pathology and cognitive function through distinct mechanisms in a T2D-AD mouse model
Experiments in miceSGLT2 inhibitors
Thursday, October 19
Nature Communications
FSH and ApoE4 contribute to Alzheimer's disease-like pathogenesis via C/EBPβ/δ-secretase in female mice
Experiments in miceAPOE
Tuesday, October 10
Molecular Neurobiology
Cognitive Deficits and Alzheimer's Disease-Like Pathologies in the Aged Chinese Tree Shrew
Experiments in animalsMechanisms
Saturday, September 9
Saturday, April 29
Wednesday, January 18
Journal of Neuroscience Research
The association of astrogliosis and microglial activation with aging and Alzheimer's disease pathology in the chimpanzee brain
Experiments in animalsMechanisms
Wednesday, January 11
International Journal of Molecular Sciences
The Rat Brain Transcriptome: From Infancy to Aging and Sporadic Alzheimer's Disease-like Pathology
Experiments in ratsMechanisms
Monday, December 19
Acta Neuropathologica Communications
Cognitively impaired aged Octodon degus recapitulate major neuropathological features of sporadic Alzheimer's disease
Experiments in animalsMechanisms
Thursday, December 15
The European Journal of Neuroscience
Alzheimer's disease-like neuropathology in three species of oceanic dolphin
Experiments in animalsMechanisms
Tuesday, November 29
Journal of Alzheimer's Disease
Beneficial Effect of a Small Pharmacologic Chaperone on the Established Alzheimer's Disease Phenotype
Experiments in miceAlzheimer's disease
Tuesday, November 22
Brain Research
Dysregulation of sphingosine-1-phosphate (S1P) and S1P receptor 1 signaling in the 5xFAD mouse model of Alzheimer's disease
Experiments in animalsMechanisms
Saturday, October 15
Human Molecular Genetics
NRSF regulates age-dependently cognitive ability and its conditional knockout in APP/PS1 mice moderately alters AD-like pathology
Experiments in miceAPP
Friday, October 14
The European Journal of Neuroscience
Impaired spatial navigation and age-dependent hippocampal synaptic dysfunction are associated with chronic inflammatory response in db/db mice
Experiments in animalsMechanisms
Tuesday, June 21
Journal of Alzheimer's Disease
Characterization of Early Alzheimer's Disease-Like Pathological Alterations in Non-Human Primates with Aging: A Pilot Study
Experiments in 6 monkeysMechanisms
Wednesday, March 16
Tuesday, December 28
Progress in Neurobiology
Neuronal ApoE4 stimulates C/EBPβ activation, promoting Alzheimer's disease pathology in a mouse model
Experiments in miceAPOE
Tuesday, December 21
International Journal of Molecular Sciences
The Dynamics of β-Amyloid Proteoforms Accumulation in the Brain of a 5xFAD Mouse Model of Alzheimer's Disease
Experiments in miceMechanisms
Friday, October 29
Frontiers in Integrative Neuroscience
Disruption of Glucose Metabolism in Aged Octodon degus: A Sporadic Model of Alzheimer's Disease
Experiments in animalsMechanisms
Monday, October 18
Food and Chemical Toxicology
Methylglyoxal affects cognitive behaviour and modulates RAGE and Presenilin-1 expression in hippocampus of aged mice
Experiments in miceMechanisms
Friday, August 20
GeroScience
Canine Cognitive Dysfunction (CCD) scores correlate with amyloid beta 42 levels in dog brain tissue
Experiments in dogsMechanisms
Wednesday, August 4
Brain, Behavior, and Immunity
Early monocyte modulation by the non-erythropoietic peptide ARA 290 decelerates AD-like pathology progression
Experiments in animalsInterventions
Thursday, July 22
bioRxiv
Characterization of early Alzheimer’s-like pathological alterations in non-human primates with aging: a pilot study
Preprint: experiments in 6 monkeysMechanisms
Monday, January 18
Research Square
Systemic inflammation causes microglial dysfunction with a mixed AD-like pathology
Preprint: experiments in miceInflammation