Papers on AD-like pathology

91 papers4 new in 30 days

Thursday, October 29

CellsOct 29

Functional Deficits and Diffusion Tensor Magnetic Resonance Imaging of the Olfactory and Vision Systems in the Alzheimer’s Disease Model of Aging GluN3A Knockout Mice

Experiments in miceMechanisms

Paper

Tuesday, October 27

Acta PharmaceuticaOct 27

Relaxin-2 protects synaptic integrity via hippocampal NLRP3-mTOR-autophagy pathways in an age-dependent Alzheimer-like model

Experiments in miceAlzheimer's disease

Paper

Saturday, October 24

Experimental NeurologyOct 24

NEFL contributes to DJ-1-mediated neuroprotection and autophagic flux regulation in Alzheimer's disease-like injury

Experiments in miceAutophagy

Paper

Thursday, October 8

NPJ DementiaOct 8

Alzheimer's disease neuropathological characterization of the dog brain and relationship to biofluid biomarkers and cognitive function

Study design and methodological overview.

Study of 24 dogsAlzheimer's disease

Paper

Saturday, September 26

Experimental Brain ResearchSep 26

High-intensity interval training modulates APP expression and reduces neuronal apoptosis in a β-amyloid-induced model of Alzheimer's disease: hippocampal evidence

Experimental timeline of the HIIT protocol in a β-amyloid-induced Alzheimer’s model.

Experiments in 60 ratsHigh-intensity interval training

Paper

Sunday, September 6

Journal of Molecular HistologySep 6

The neuroprotective potential of thymoquinone and intermittent fasting on aluminum chloride-induced Alzheimer's disease like model in rat hippocampus: insights into neurogenesis and autophagy

Experiments in 80 ratsIntermittent fasting

Paper

Thursday, August 27

Research SquareAug 27

Low-dose lithium prevents age-dependent metabolic stress–driven alzheimer’s disease–like pathology through restoration of the NAMPT–NAD⁺–SIRT1–AMPK–TFEB metabolic resilience network

Preprint: experiments in miceLithium

Paper

Friday, August 14

European Journal of PharmacologyAug 14

Hippocampal Klotho expression is associated with the neuroprotective effects of metformin against ICV-STZ-induced cognitive deficits

Experiments in ratsMetformin

Paper

Saturday, June 27

Nature CommunicationsJun 27

Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology

Cohort study of 1,196 peopleMechanisms

Paper

Tuesday, May 19

Oxidative Medicine and Cellular LongevityMay 19

Intermittent Fasting Potentiates Aerobic Exercise to Reduce Hippocampal Amyloid Burden and Oxidative Stress via Suppression of NF-κB/NLRP3 Signaling in an Aβ-Injected Rat Model

Experiments in ratsIntermittent fasting

Paper

Wednesday, May 13

Molecular and Cellular BiochemistryMay 13

Semaglutide ameliorates neuroinflammation and cognitive impairment in APP/PS1 mice

Experiments in miceSemaglutide

Paper

Monday, May 4

Naunyn-Schmiedeberg's Archives of PharmacologyMay 4

Dual protective role of curcumin- encapsulated chitosan nanoparticles against gastric and neural injury in a rat model of gut-brain axis dysfunction: a histological and biochemical study

Experiments in ratsCurcumin

Paper

Tuesday, April 7

Journal of EthnopharmacologyApr 7

A specific pilose antler peptide LVLVEAELRE ameliorates cognitive deficits in SAMP8 mice via Celsr2

Experiments in miceInterventions

Paper

Wednesday, April 1

Tissue & CellApr 1

Semaglutide treatment reverses HFD induced hippocampal microglia activation and improves cognitive dysfunction

Experiments in miceSemaglutide

Paper

Lishizhen Medicine and Materia Medica ResearchApr 1

Jiannao Bushen Oral Liquid （Jiannao Bushen Oral Liquid） ameliorates cognitive function in Alzheimer’s disease mice by suppressing oxidative stress via the cGAS/STING pathway

Experiments in 30 miceAlzheimer's disease

Paper

Friday, March 20

Current Opinion in Clinical Nutrition and Metabolic CareMar 20

Nutrition and gut-brain axis: opposing effects of dietary fiber and Western-style diets on Alzheimer's disease

ReviewGut and microbiome

Paper

Monday, March 16

Research SquareMar 16

Alzheimer's Disease Neuropathological characterization of the dog brain and relationship to biofluid biomarkers and cognitive function

Preprint: experiments in 24 dogsMechanisms

Paper

Monday, December 29

Aging CellDec 29

The 3xTg-AD Mouse Model of Alzheimer's Disease Exhibits Lifelong Reductions in Circulating Choline Despite Adequate Dietary Intake, With Sex-Specific Neuropathological and Behavioral Phenotypes

Experiments in miceMechanisms

Paper

Saturday, December 27

Free Radical Biology & MedicineDec 27

Eleutheroside B ameliorates AD-like pathological features in Caenorhabditis elegans by inducing autophagy and combating oxidative stress

Experiments in wormsInterventions

Paper

Wednesday, December 3

bioRxivDec 3

Anterior thalamic nucleus inputs to the retrosplenial cortex are unperturbed in the hAPP-J20 mouse model of Alzheimer’s disease

Preprint: experiments in animalsMechanisms

Paper

Sunday, November 30

Alzheimer's Research & TherapyNov 30

Single-cell analysis reveals shared and distinct molecular signatures in brain organoid models of neurodegeneration and neuroinflammation

Computational studyMechanisms

Paper

Thursday, October 9

Frontiers in Aging NeuroscienceOct 9

Quantitative analysis of serum metabolites in a rat model of Alzheimer's disease

Experiments in ratsAlzheimer's disease

Paper

Friday, September 26

CellsSep 26

PF-04691502, a PI3K/mTOR Dual Inhibitor, Ameliorates AD-like Pathology in a Mouse Model of AD

Experiments in miceInterventions

Paper

Monday, July 28

Translational NeurodegenerationJul 28

Long-term exercise enhances meningeal lymphatic vessel plasticity and drainage in a mouse model of Alzheimer's disease

Experiments in miceExercise

Paper

Thursday, June 5

Translational NeurodegenerationJun 5

Aging-dependent YAP1 reduction contributes to AD pathology by upregulating the Nr4a1-AKT/GSK-3β axis

Experiments in miceYAP1

Paper

Monday, May 12

Molecular Nutrition & Food ResearchMay 12

Neuroprotective Potential of the Flavonoids Quercetin and Epicatechin in a C. elegans Tauopathy Model

Experiments in wormsQuercetin

Paper

Monday, April 21

Biochemistry BiokhimiiaApr 21

JNK Signaling Pathway Activity Alterations in the Rat Hippocampus: Effect of Age, Alzheimer's Disease-Like Pathology Development, and the JNK Inhibitor IQ-1S

Experiments in ratsJNK signaling

Paper

Wednesday, January 22

Molecular Nutrition & Food ResearchJan 22

Intermittent Fasting Ameliorates β-Amyloid Deposition and Cognitive Impairment Accompanied by Decreased Lipid Droplet Aggregation Within Microglia in an Alzheimer's Disease Model

Experiments in miceIntermittent fasting

Paper

Thursday, December 19

Neuromolecular MedicineDec 19

Differential Expression of GABA Receptor-Related Genes in Alzheimer's Disease and the Positive Regulatory Role of Aerobic Exercise-From Genetic Screening to D-gal-induced AD-like Pathology Model

Experiments in miceExercise

Paper

Friday, December 6

Journal of Alzheimer's DiseaseDec 6

Alzheimer's disease-like pathology induced by Porphyromonas gingivalis in middle-aged mice is mediated by NLRP3 inflammasome via the microbiota-gut-brain axis

Experiments in miceNLRP3 inflammasome

Paper