AD-like pathology

1. AD-like pathology is associated with amyloid-beta 1-42 in rats (advanced stage of AD-like pathology).

   “There were significant alterations in the vessels and downregulation of VEGF with an increased amount of amyloid β1−42 there at the advanced stage of the disease.”

   Animalsadvanced stage of AD-like pathologyhippocampus

   Association of cerebrovascular dysfunction with the development of Alzheimer's disease-like pathology in OXYS rats

   BMC genomics·Feb 9, 2018

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1. AD-like pathology is associated with VEGF in rats (advanced stage of AD-like pathology).

   “There were significant alterations in the vessels and downregulation of VEGF with an increased amount of amyloid β1−42 there at the advanced stage of the disease.”

   Animalsadvanced stage of AD-like pathologyhippocampus

   Association of cerebrovascular dysfunction with the development of Alzheimer's disease-like pathology in OXYS rats

   BMC genomics·Feb 9, 2018

More on VEGF

1. AD-like pathology is associated with cerebrovascular function in rats (advanced stage, compared with Wistar rats).

   “At the advanced stage in OXYS rats, differentially expressed genes (DEGs) were associated with downregulation of cerebrovascular function as compared to Wistar rats.”

   Animalsadvanced stage, compared with Wistar ratshippocampus

   Association of cerebrovascular dysfunction with the development of Alzheimer's disease-like pathology in OXYS rats

   BMC genomics·Feb 9, 2018

1. AD-like pathology is associated with hippocampal blood vessel density in rats (early stage of AD-like pathology in OXYS rats).

   “We observed a loss of hippocampal blood vessel density and ultrastructural changes of those blood vessels in OXYS rats at the early stage of AD-like pathology.”

   Animalsearly stage of AD-like pathology in OXYS ratshippocampus

   Association of cerebrovascular dysfunction with the development of Alzheimer's disease-like pathology in OXYS rats

   BMC genomics·Feb 9, 2018

1. AD-like pathology is associated with mitochondrial fission and fusion in rats.

   “with increased fission”

   Animalshippocampus

   Mitochondrial Dysfunction as a Predictor and Driver of Alzheimer's Disease-Like Pathology in OXYS Rats

   Journal of Alzheimer's disease : JAD·Jan 1, 2018

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1. AD-like pathology is associated with mitochondrial number in rats (dramatic decrease).

   “Signs of AD developed simultaneously with increasing dysfunction of mitochondria, with a dramatic decrease in their number”

   Animalshippocampus

   Mitochondrial Dysfunction as a Predictor and Driver of Alzheimer's Disease-Like Pathology in OXYS Rats

   Journal of Alzheimer's disease : JAD·Jan 1, 2018

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1. AD-like pathology is associated with respiratory chain complex activities in rats.

   “including decreased activity of respiratory complexes against the background of greater fusion”

   Animalshippocampus

   Mitochondrial Dysfunction as a Predictor and Driver of Alzheimer's Disease-Like Pathology in OXYS Rats

   Journal of Alzheimer's disease : JAD·Jan 1, 2018

More on Respiratory chain complex activities

1. AD-like pathology is associated with hippocampal mitochondrial size in rats.

   “Already at the preclinical stage, OXYS rats showed some characteristic changes in hippocampal mitochondria, which increased in size with the manifestation and progression of AD-like pathology”

   Animalshippocampus

   Mitochondrial Dysfunction as a Predictor and Driver of Alzheimer's Disease-Like Pathology in OXYS Rats

   Journal of Alzheimer's disease : JAD·Jan 1, 2018

More on Hippocampal mitochondrial size