Research Square
Systemic Inflammation Causes Microglial Dysfunction With a Mixed Ad-like Pathology
Preprint: experiments in miceInflammation
Papers on AD-like pathology
93 papers4 new in 30 days
Monday, September 28
Tuesday, September 22
Philosophical Transactions of the Royal Society of London, Series B
Neuron loss associated with age but not Alzheimer's disease pathology in the chimpanzee brain
Experiments in animalsMechanisms
Wednesday, September 16
International Journal of Molecular Sciences
Both Amyloid-β Peptide and Tau Protein Are Affected by an Anti-Amyloid-β Antibody Fragment in Elderly 3xTg-AD Mice
Experiments in animalsInterventions
Saturday, August 1
Tuesday, July 28
bioRxiv
Systemic inflammation causes microglial dysfunction with a mixed AD-like pathology
Preprint: study in peopleInflammation
Thursday, November 14
International Journal of Molecular Sciences
Mechanisms of Neuronal Death in the Cerebral Cortex during Aging and Development of Alzheimer's Disease-Like Pathology in Rats
Experiments in animalsMechanisms
Thursday, September 12
Molecular and Cellular Neurosciences
The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice
Experiments in miceInterventions
Frontiers in Aging Neuroscience
High-Fat Diet Increases Amylin Accumulation in the Hippocampus and Accelerates Brain Aging in hIAPP Transgenic Mice
Experiments in animalsMechanisms
Friday, June 28
Frontiers in Pharmacology
Astrocyte Function Is Affected by Aging and Not Alzheimer's Disease: A Preliminary Investigation in Hippocampi of 3xTg-AD Mice
Experiments in miceMechanisms
Friday, November 30
Aging Cell
Temporal and regional progression of Alzheimer's disease-like pathology in 3xTg-AD mice
Experiments in miceMechanisms
Saturday, November 10
Journal of Alzheimer's Disease
New Insights into the Spontaneous Human Alzheimer's Disease-Like Model Octodon degus: Unraveling Amyloid-β Peptide Aggregation and Age-Related Amyloid Pathology
Experiments in miceMechanisms
Tuesday, November 6
Pharmacological Research
Pseudoginsenoside-F11 alleviates cognitive deficits and Alzheimer's disease-type pathologies in SAMP8 mice
Experiments in animalsInterventions
Thursday, October 4
Scientific Reports
Chronic noise exposure exacerbates AD-like neuropathology in SAMP8 mice in relation to Wnt signaling in the PFC and hippocampus
Experiments in animalsMechanisms
Saturday, September 29
The Journals of Gerontology, Series A
The Rat Prefrontal-Cortex Transcriptome: Effects of Aging and Sporadic Alzheimer's Disease-Like Pathology
Experiments in ratsMechanisms
Thursday, September 20
Experimental Neurology
Early intrathecal infusion of everolimus restores cognitive function and mood in a murine model of Alzheimer's disease
Experiments in miceAlzheimer's disease
Thursday, August 30
Journal of Neuroinflammation
APP21 transgenic rats develop age-dependent cognitive impairment and microglia accumulation within white matter tracts
Experiments in animalsMechanisms
Friday, August 3
The Journal of Comparative Neurology
Microglia changes associated to Alzheimer's disease pathology in aged chimpanzees
Experiments in animalsMechanisms
Wednesday, May 2
Journal of Alzheimer's Disease
Mitochondrial Dysfunction as a Predictor and Driver of Alzheimer's Disease-Like Pathology in OXYS Rats
Experiments in ratsOxidative phosphorylation
Tuesday, March 6
Monday, August 7
Progress in Neuro-psychopharmacology & Biological Psychiatry
Differential effects of voluntary treadmill exercise and caloric restriction on tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology fed with Western diet
Experiments in miceDietary restriction
Sunday, June 18
Frontiers in Aging Neuroscience
Slow and Fast Neocortical Oscillations in the Senescence-Accelerated Mouse Model SAMP8
Experiments in miceMechanisms
Thursday, March 23
Biochemistry Biokhimiia
Impact of Changes in Neurotrophic Supplementation on Development of Alzheimer's Disease-Like Pathology in Oxys Rats
Experiments in ratsMechanisms
Thursday, November 10
Saturday, September 10
Molecular Neurobiology
SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms
Experiments in miceInterventions
Sunday, June 12
Sunday, May 29
Journal of Agricultural and Food Chemistry
Effects of Sesaminol Feeding on Brain Aβ Accumulation in a Senescence-Accelerated Mouse-Prone 8
Experiments in miceInterventions
Thursday, May 5
Saturday, April 2
Neural Plasticity
A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice
Experiments in miceInterventions
Tuesday, February 2
Neurobiology of Aging
Alzheimer's disease-like pathology has transient effects on the brain and blood metabolome
Experiments in miceAmino acid metabolism
Monday, August 25
The Journal of Biological Chemistry
Methylene blue modulates β-secretase, reverses cerebral amyloidosis, and improves cognition in transgenic mice
Experiments in miceInterventions