Undercarboxylated osteocalcin

Biomarker1 paper2 findings

  • Humans1

Associations

2

Medial prefrontal cortex grey matter volume

upin humans1

1 study
  1. Undercarboxylated osteocalcin is associated with medial prefrontal cortex grey matter volume in humans.

    Humansin osteoporosis patients

    Osteocalcin links brain volume to cognition in osteoporosis · Frontiers in neurology · 16 Sep 2026

Medial prefrontal cortex grey matter volume →

Cognitive function

upin humans1

1 study
  1. Undercarboxylated osteocalcin is associated with cognitive function in humans.

    Humansin osteoporosis patients

    Osteocalcin links brain volume to cognition in osteoporosis · Frontiers in neurology · 16 Sep 2026

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Frontiers in NeurologyHumans

Osteocalcin links brain volume to cognition in osteoporosis

In people with osteoporosis, higher undercarboxylated osteocalcin correlated with greater medial prefrontal cortex volume, which predicted one-year…In people with osteoporosis, higher undercarboxylated osteocalcin correlated with greater medial prefrontal cortex volume, which predicted one-year cognitive decline with an AUC of 0.84.