Medial prefrontal cortex grey matter volume

Biomarker1 paper3 findings

  • Humans1

Effects

1

Cognitive function

mediatesin humans1

1 study
  1. Medial prefrontal cortex grey matter volume mediates cognitive function in humans.

    Humansbetween ucOC and cognitive function in osteoporosis patients

    Osteocalcin links brain volume to cognition in osteoporosis · Frontiers in neurology · 16 Sep 2026

Associations

2

Undercarboxylated osteocalcin

upin humans1

1 study
  1. Undercarboxylated osteocalcin is associated with medial prefrontal cortex grey matter volume in humans.

    Humansin osteoporosis patients

    Osteocalcin links brain volume to cognition in osteoporosis · Frontiers in neurology · 16 Sep 2026

Undercarboxylated osteocalcin →

Cognitive decline

upin humans1

1 study
  1. Medial prefrontal cortex grey matter volume predicts cognitive decline in humans (AUC = 0.84, 95% CI [0.79, 0.88]).

    Humansin osteoporosis patients1-year

    Osteocalcin links brain volume to cognition in osteoporosis · Frontiers in neurology · 16 Sep 2026

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Frontiers in NeurologyHumans

Osteocalcin links brain volume to cognition in osteoporosis

In people with osteoporosis, higher undercarboxylated osteocalcin correlated with greater medial prefrontal cortex volume, which predicted one-year…In people with osteoporosis, higher undercarboxylated osteocalcin correlated with greater medial prefrontal cortex volume, which predicted one-year cognitive decline with an AUC of 0.84.