Transcriptomic signatures of aging

1 paper1 finding

Animals1

Upstream

1

TP53

downin mice1

1 study

TP53 decreases transcriptomic signatures of aging in mice.
“Activation of p53 in aged mice by pharmacological inhibition of MDM2 reverses transcriptomic signatures of aging”
Animalsliver
p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells
Nature communications5 Mar 2025

Latest

1 in 12 months

bioRxiv20 Aug

Single-cell foundation models identify shared and divergent transcriptomic signatures of aging across invertebrates and mammals

Preprint: computational studyFoundation models

Nature Communications5 Mar

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells

Experiments in miceDNA repair

GSA 2024 Abstract1 Jan

PARTIAL REPROGRAMMING OF THE AGING NEUROGENIC NICHE

Experiments in miceInterventions