Macrophage content
Biomarker2 papers2 findings
- Animals2
Interventions
1ANTI-IL-21R monoclonal antibody
downin mice1Very low certainty
1 study
ANTI-IL-21R monoclonal antibody
downin mice1Very low certainty
ANTI-IL-21R monoclonal antibody decreases macrophage content in mice (-61% (p = 0.053)).
Animalsyoung Ldlr-/- mice
IL-21R blockade reduces inflammation and atherosclerosis in LDL receptor deficient mice · Atherosclerosis · 3 Sep 2026
Associations
1Cellular senescence
upin mice1
1 study
Cellular senescence
upin mice1
Cellular senescence is associated with macrophage content in mice.
Animalsaging kidneykidney
Insights Into the Interplay Between the Senescent Cells and Immune Cells · Aging cell · 1 Sep 2026
Funding
National Institute on AgingUS$4.9mNational Heart, Lung, and Blood InstituteUS$4.6mNational Institute on Drug AbuseUS$1.5m25 grants since 2017
Macrophage Function During Muscle Regeneration in Older Adults
National Institute on AgingUniversity of UtahUS$138.6k2026–2031
The Post-Lung Transplant Impact of Alveolar Macrophage Senescence in Aged Donor Lungs
National Heart, Lung, and Blood InstituteDuke UniversityUS$154.4k2025–2030
Macrophage spatial heterogeneity in regulating hematopoietic aging
National Institute on AgingUniversity of RochesterUS$227.3k2026–2028
Deciphering how tissue resident macrophages regulate musculoskeletal regeneration in spiny mice
National Institute of Arthritis and Musculoskeletal and Skin DiseasesUniversity of KentuckyUS$541.7k2017–2029
Macrophage/Microglia dysfunction in age-related auditory nerve degeneration
National Institute on Deafness and Other Communication DisordersMedical University of South CarolinaUS$52k2025–2027
A Drosophila model to understand the role of aging macrophages in epithelial wound healing
National Institute on AgingUniversity of California, BerkeleyUS$47.7k2026–2028
Plaque and blood derived macrophages: a multi-omic assessment of CVD pathogenesis in PLWH
National Heart, Lung, and Blood InstituteOhio State UniversityUS$818.7k2021–2030
Mechanisms controlling macrophage response during heart regeneration in zebrafish
National Heart, Lung, and Blood InstituteEmory UniversityUS$498.2k2026–2030
The role of macrophage metabolism and age in recovery from spinal cord injury
National Institute of Neurological Disorders and StrokeUniversity of KentuckyUS$540.9k2023–2028
Immunometabolic regulation of inflammaging by nerve-associated macrophages
National Institute on AgingYale UniversityUS$544.3k2026–2031