Transcriptional noise

Irregular estrous cycling is associated with transcriptional noise in mice.

“irregularly cycling ovaries exhibited accelerated aging and cellular senescence features compared with regularly cycling counterparts, including increased transcriptional noise”

AnimalsDuring the estropausal transition, compared with regularly cycling ovariesovary

Single-cell atlas of the mouse ovary reveals molecular drivers of aging and senescence during the estropausal transition

Proceedings of the National Academy of Sciences of the United States of America·21 Jul 2026