1 paper1 finding
Aminoglycosides
upin human cells1
Aminoglycosides induce transcriptional changes in human cells.
“Following aminoglycoside-induced damage, we detect early transcriptional changes consistent with a capacity to respond to ototoxic damage within 24 hours”
Cellsaminoglycoside-induced damageutricle24 hours
Revealing heterogeneity and damage response in the adult human utricle
Nature communications11 Dec 2025
Three weeks of protein injections reduced weight in male and female mice, with greater effects in older mice and those fed a high-fat diet.Three weeks of protein injections reduced weight in male and female mice, with greater effects in older mice and those fed a high-fat diet.
Analyses of human kidney tumours, mice and cell lines showed that losing the Y chromosome produces few broad changes in gene activity across cancers.Analyses of human kidney tumours, mice and cell lines showed that losing the Y chromosome produces few broad changes in gene activity across cancers.
In 45 patients with heart failure with preserved ejection fraction, diet and exercise partially reversed altered gene activity and DNA packaging in muscle.In 45 patients with heart failure with preserved ejection fraction, diet and exercise partially reversed altered gene activity and DNA packaging in muscle.
An observational study of 223 healthy people aged 1 to 90 found relatively stable patterns in this immune cell group across adulthood.An observational study of 223 healthy people aged 1 to 90 found relatively stable patterns in this immune cell group across adulthood.
Diminished SATB1 in murine naive CD4⁺ T cells weakens TAD boundaries, rewires enhancer-promoter interactions, and increases proinflammatory gene expression during aging.Diminished SATB1 in murine naive CD4⁺ T cells weakens TAD boundaries, rewires enhancer-promoter interactions, and increases proinflammatory gene expression during aging.
Fibroblasts from individuals at risk for rheumatoid arthritis exhibit impaired adipogenic differentiation and downregulated DNA repair and cell cycle pathways.Fibroblasts from individuals at risk for rheumatoid arthritis exhibit impaired adipogenic differentiation and downregulated DNA repair and cell cycle pathways.