Somatic mutation burden

1. Platinum chemotherapy increases somatic mutation burden in humans.

   Humansin normal pediatric tissues

   Extensive and differential platinum chemotherapy mutagenesis in livers of children · Science (New York, N.Y.) · 10 Sep 2026

Platinum chemotherapy →

1. Caloric restriction decreases somatic mutation burden in mice.

   Animals

   Caloric restriction modulates genome-wide somatic mutation in mice · Cell · 9 Sep 2026

Caloric restriction →

1. centromeres are associated with somatic mutation burden in humans.

   “Donor-specific assemblies uncovered elevated mutation rates within centromeres and segmental duplications inaccessible to standard reference genomes”

   Humansrevealed by donor-specific assembliesn = 25

   Integrated map of somatic mosaicism across human tissues in 25 individuals · bioRxiv · 3 Sep 2026 · Preprint

1. Transcriptomic entropy is associated with somatic mutation burden in silico.

   In silico

   Tissue-Level Transcriptomic Entropy Reveals Organ-Specific Aging Patterns and Predicts Cancer Progression · Aging cell · 1 Sep 2026

Transcriptomic entropy →