Mutational signature

Biomarker1 paper3 findings

Humans1

Interventions

1

Platinum chemotherapy

upin humans1Low certainty

1 study

Platinum chemotherapy induces mutational signature in humans.
Humansin normal tissues of childrenliver
Extensive and differential platinum chemotherapy mutagenesis in livers of children · Science (New York, N.Y.) · 10 Sep 2026

Platinum chemotherapy →

Effects

1

Cancer driver variants in the VHL gene

upin humans1

1 study

Mutational signature increases cancer driver variants in the VHL gene in humans.
Humanskidney
Single genome analysis of normal cells identifies the early steps of kidney cancer · bioRxiv · 7 Sep 2026 · Preprint

Associations

1

Clear cell renal cell carcinoma

upin humans1+96%

1 study

Mutational signature is associated with clear cell renal cell carcinoma in humans (96%).
Humanskidney
Single genome analysis of normal cells identifies the early steps of kidney cancer · bioRxiv · 7 Sep 2026 · Preprint

Clear cell renal cell carcinoma →

Latest

7

CarcinogenesisReview5 Oct

Air pollution and early-onset lung cancer: from environmental carcinogenesis to early intervention strategies

The European Journal of NeuroscienceReview18 Sep

Somatic Mosaicism of the Brain: The Functional Implications of Post-Zygotic Mutations to Neural Circuits

medRxivHumansPreprint17 Sep

Intense TP53 pathway selection drives clonal evolution from bone marrow failure to leukemia in ERCC6L2 disease

Bones and joints

ScienceHumans10 Sep

Extensive and differential platinum chemotherapy mutagenesis in livers of children

Archives of ToxicologyHumans8 Sep

Genotoxicity threshold for methyl methacrylate in Chinese workers: a novel multi-endpoint genotoxicity assessment incorporating biological aging

bioRxivHumansPreprint7 Sep

Single genome analysis of normal cells identifies the early steps of kidney cancer

AAIC 2025 AbstractHumans23 Dec

Neurons accumulate disease‐specific somatic deletions across tau pathological states in Alzheimer’s disease