Integrated map of somatic mosaicism across human tissues in 25 individuals
bioRxiv
Abstract
Although all cells in the body descend from one genome, they accumulate distinct genetic and epigenetic changes over a lifetime, producing a mosaic of somatic variation that can shape development, aging, and disease. This mosaicism is often studied in isolation, leaving unclear how these forms relate within and between individuals.
- Resources: datasets, atlases and tools
- Chromatin and 3D genome organisation
- DNA methylation
- Transposable element activity
- Somatic mutation burden
- Humans
The paper
The Somatic Mosaicism across Human Tissues Network, Sedlazeck FJ, Coorens THH et al.
bioRxiv · 3 Sep 2026 · CC BY · Preprint, not peer-reviewed
