Soluble amyloid-beta
3 papers2 findings
- Animals2
Interventions
1Spermidine
downin reviews1
1 study
Spermidine
downin reviews1
Spermidine decreases soluble amyloid-beta.
“Preclinical studies consistently show that spermidine enhances proteostasis, reduces soluble amyloid-beta”
Reviewpreclinical models of aging and neurodegeneration
Spermidine in the aging brain: mechanisms, preclinical evidence, and clinical perspectives
Molecular biology reports21 Apr 2026
Upstream
1APP
upin mice1
1 study
APP
upin mice1
APP increases soluble amyloid-beta in mice (33-fold).
“soluble A beta levels in the brain were continually elevated, increasing 4-fold at 2 months and 33-fold in the APP23 Tg mice at 20 months of age when compared to the control mice.”
Animalsin APP23 Tg mice compared to control micebrain
Molecular medicine (Cambridge, Mass.)1 Sep 2001
Latest
3 in 12 monthsAnalytica Chimica Acta
Magnetic-assisted catalytic hairpin assembly fluorescent aptasensor for highly sensitive detection of amyloid-beta oligomers as Alzheimer's disease biomarker
Cross-sectional study in peopleAlzheimer's disease
Molecular Biology Reports
Spermidine in the aging brain: mechanisms, preclinical evidence, and clinical perspectives
ReviewSpermidine
Molecular Medicine
The evolution of A beta peptide burden in the APP23 transgenic mice: implications for A beta deposition in Alzheimer disease
Experiments in miceMechanisms