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Cerivastatin

Cerivastatin has been studied in 2 papers since 2007: 1 observational study in people, 1 in animals. The newest paper, Jun 18, 2017: “Lipophilic Statins and the Risk of Intracranial Hemorrhage Following Ischemic Stroke: A Population-Based Study”.

Intervention

2 papers study it4 findingsUpdated

PubChemChEBIMeSH

See all 2 papers on cerivastatin

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

Mice: a single group. Cells, worms or flies and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Humans1
  • Animals1

What did studies of cerivastatin find?

4

Studies of cerivastatin measured 4 outcomes; the most studied are extracellular matrix remodeling (1 study), serum urea (1) and proteinuria (1).

Extracellular matrix remodeling

downin mice1

1 study

  1. Cerivastatin decreases extracellular matrix remodeling in mice (COL4A3 knockout mice).

    “Deposition of laminin and fibronectin, expression of TGF-beta and CTGF was reduced.”

    AnimalsCOL4A3 knockout micekidney

    Nephroprotective effect of the HMG-CoA-reductase inhibitor cerivastatin in a mouse model of progressive renal fibrosis in Alport syndrome

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

More on Extracellular matrix remodeling

Serum urea

downin mice1

1 study

  1. Cerivastatin decreases serum urea in mice (COL4A3 knockout mice) (164 vs 235 mmol/l).

    “Early cerivastatin treatment reduced cholesterol levels (113+/-13 vs 141+/-19 mmol/l in untreated animals, P<0.05) and serum urea (164 vs 235 mmol/l, day 66, P<0.05).”

    AnimalsCOL4A3 knockout mice

    Nephroprotective effect of the HMG-CoA-reductase inhibitor cerivastatin in a mouse model of progressive renal fibrosis in Alport syndrome

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

More on Serum urea

Proteinuria

downin mice1

1 study

  1. Cerivastatin decreases proteinuria in mice (COL4A3 knockout mice) (5.5 vs 12 g/l).

    “Treatment also decreased proteinuria (5.5 vs 12 g/l at day 66, P<0.05).”

    AnimalsCOL4A3 knockout mice

    Nephroprotective effect of the HMG-CoA-reductase inhibitor cerivastatin in a mouse model of progressive renal fibrosis in Alport syndrome

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

More on Proteinuria

Lifespan

upin mice1

1 study

  1. Cerivastatin extends lifespan in mice (COL4A3 knockout mice) (+28% (71+/-6 vs 91+/-9 days)).

    “The lifespan of treated COL4A3 knockout mice was increased by 28% compared with untreated animals (71+/-6 vs 91+/-9 days, P<0.01).”

    AnimalsCOL4A3 knockout mice

    Nephroprotective effect of the HMG-CoA-reductase inhibitor cerivastatin in a mouse model of progressive renal fibrosis in Alport syndrome

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

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